The Varied Roles of Notch in Cancer

被引：522

作者：

Aster, Jon C. ^{[1
,2
]}

Pear, Warren S. ^{[3
]}

Blacklow, Stephen C. ^{[4
]}

机构：

[1] Brigham & Womens Hosp, Dept Pathol, 75 Francis St, Boston, MA 02115 USA

[2] Harvard Med Sch, Boston, MA 02115 USA

[3] Univ Penn, Perelman Sch Med, Abramson Family Canc Res Inst, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA

[4] Harvard Med Sch, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USA

来源：

ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 12 | 2017年 / 12卷

关键词：

cancer hallmarks; cellular transformation; Notch; oncogene; tumor suppressor; ACUTE LYMPHOBLASTIC-LEUKEMIA; T-CELL LEUKEMIA; ADENOID CYSTIC CARCINOMA; CHRONIC LYMPHOCYTIC-LEUKEMIA; MARGINAL ZONE LYMPHOMA; OF-FUNCTION MUTATIONS; ADAMS-OLIVER SYNDROME; STEM-LIKE CELLS; DELTA-LIKE; NEGATIVE REGULATORY REGION;

D O I：

10.1146/annurev-pathol-052016-100127

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Notch receptors influence cellular behavior by participating in a seemingly simple signaling pathway, but outcomes produced by Notch signaling are remarkably varied depending on signal dose and cell context. Here, after briefly reviewing new insights into physiologic mechanisms of Notch signaling in healthy tissues and defects in Notch signaling that contribute to congenital disorders and viral infection, we discuss the varied roles of Notch in cancer, focusing on cell autonomous activities that may be either oncogenic or tumor suppressive.

引用

页码：245 / 275

页数：31

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