Drug delivery systems based on CD44-targeted glycosaminoglycans for cancer therapy

被引：90
作者：
Li, Min [1 ,2 ]
Sun, Jiao [2 ]
Zhang, Wenjun [3 ]
Zhao, Yinan [2 ]
Zhang, Shufen [1 ]
Zhang, Shubiao [2 ]
机构：
[1] Dalian Univ Technol, State Key Lab Fine Chem, Dalian 116023, Peoples R China
[2] Dalian Minzu Univ, Key Lab Biotechnol & Bioresources Utilizat, Minist Educ Life Sci, Dalian 116600, Peoples R China
[3] Dalian Univ Technol, Sch Chem Engn, Panjin 124221, Peoples R China
来源：
CARBOHYDRATE POLYMERS | 2021年 / 251卷
基金：
中国国家自然科学基金;
关键词：
Drug delivery; Nanoparticles; CD44; target; Hyaluronic acid; Chondroitin sulfate; CONJUGATED CHONDROITIN SULFATE; REDOX-SENSITIVE MICELLES; UP-CONVERSION NANOPARTICLES; ACID-PACLITAXEL CONJUGATE; IRON-OXIDE NANOPARTICLES; MODIFIED HYALURONIC-ACID; BREAST-CANCER; PHOTODYNAMIC THERAPY; MULTIDRUG-RESISTANCE; ANTICANCER DRUG;
D O I：
10.1016/j.carbpol.2020.117103
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
The polysaccharide-based biomaterials hyaluronic acid (HA) and chondroitin sulfate (CS) have aroused great interest for use in drug delivery systems for tumor therapy, as they have outstanding biocompatibility and great targeting ability for cluster determinant 44 (CD44). In addition, modified HA and CS can self-assemble into micelles or micellar nanoparticles (NPs) for targeted drug delivery. This review discusses the formation of HA-and CS-based NPs, and various types of CS-based NPs including CS-drug conjugates, CS-polymer NPs, CS-small molecule NPs, polyelectrolyte nanocomplexes (PECs), CS-metal NPs, and nanogels. We then focus on the applications of HA- and CS-based NPs in tumor chemotherapy, gene therapy, photothermal therapy (PTT), photodynamic therapy (PDT), sonodynamic therapy (SDT), and immunotherapy. Finally, this review is expected to provide guidelines for the development of various HA- and CS-based NPs used in multiple cancer therapies.
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页数：20
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