Analysis of stereoisomers of chiral drug by mass spectrometry

被引：41
作者：
Chen, Xiaolei [1 ]
Kang, Yu [1 ]
Zeng, Su [1 ]
机构：
[1] Zhejiang Univ, Inst Drug Metab & Pharmaceut Anal, Coll Pharmaceut Sci, Zhejiang Prov Key Lab Anticanc Drug Res, Hangzhou 310058, Zhejiang, Peoples R China
来源：
CHIRALITY | 2018年 / 30卷 / 05期
基金：
中国国家自然科学基金;
关键词：
analysis; chiral drug; mass spectrometry; stereoisomers; ION MOBILITY SPECTROMETRY; ALPHA-AMINO-ACIDS; GAS-PHASE; KINETIC METHOD; ENANTIOMER SEPARATION; HOST COMPOUNDS; HUMAN URINE; DISCRIMINATION; DIFFERENTIATION; ELECTROSPRAY;
D O I：
10.1002/chir.22833
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Chiral molecules are of great importance in the life science since individual enantiomers may differ in biological activity, mechanism, and toxicity, making it necessary to explore efficient chiral analysis methods. Chromatography approaches are often used to differentiate enantiomers while mass spectrometry (MS) was thought to be blind in chiral analysis. With the development of MS technique, it began to play a more and more crucial part in chiral observation. In this review, we will give a detailed introduction of the analysis methods related to MS for chiral drugs, including its mechanism, applications, and future development.
引用
收藏
页码：609 / 618
页数：10
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