Direct synthesis of 3,4-dihydro-2H-pyrido[1,2-a] pyrimidines, by addition reactions with 2-aminopyridines

被引：17
作者：
Mellor, JM
Merriman, GD
Rataj, H
Reid, G
机构：
[1] Department of Chemistry, University
来源：
TETRAHEDRON LETTERS | 1996年 / 37卷 / 15期
基金：
英国工程与自然科学研究理事会;
关键词：
D O I：
10.1016/0040-4039(96)00341-3
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Reaction of 2-aminopyridines with formaldehyde and electron rich alkenes permits synthesis of pyridopyrimidines by formation of imines and subsequent addition to the alkenes in a formal aza Diels Alder reaction. The structure of the cyclic amidine products is confirmed by single crystal X-ray analysis on a neutral amidine isolated from an aminopyridine substituted with an electron withdrawing trifluoromethyl group and of a trifluoroacetate salt of an amidine obtained from 2-aminopyridine, formaldehyde and indene. These structural studies permit the regio- and stereo-chemical outcome of these addition to be defined mid compared with related processes. Copyright (C) 1996 Published by Elsevier Science Ltd
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页码：2615 / 2618
页数：4
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