Similar Outcomes among Black and White Renal Allograft Recipients

被引:38
作者
Yeates, Karen [1 ]
Wiebe, Natasha [2 ]
Gill, John [3 ]
Sima, Camelia [4 ]
Schaubel, Douglas [5 ]
Holland, David [1 ]
Hemmelgarn, Brenda [6 ]
Tonelli, Marcello [2 ]
机构
[1] Queens Univ, Dept Med, Kingston, ON K0H 1S0, Canada
[2] Univ Alberta, Dept Med, Edmonton, AB, Canada
[3] St Pauls Hosp, Dept Med, Vancouver, BC V6Z 1Y6, Canada
[4] Arbor Res Collaborat Hlth, Ann Arbor, MI USA
[5] Univ Michigan, Dept Biostat, Ann Arbor, MI 48109 USA
[6] Univ Calgary, Dept Med, Calgary, AB, Canada
来源
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY | 2009年 / 20卷 / 01期
基金
加拿大健康研究院;
关键词
RACIAL-DIFFERENCES; AFRICAN-AMERICANS; KIDNEY-TRANSPLANT; ACCESS; RACE; SURVIVAL; DISPARITIES; TACROLIMUS; ESRD; CARE;
D O I
10.1681/ASN.2007070820
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Black renal transplant recipients experience shorter graft survival than white recipients, but no published data describe the graft outcomes among black Canadian recipients. Here, we analyzed data from the Canadian national renal replacement therapy registry, which included 20,243 incident dialysis patients (3% black, 97% white), 5036 of whom received a renal transplant during the study period. Black patients were significantly less likely to receive a renal transplant (deceased and living-donor combined) when compared with white patients (hazard ratio 0.59; 95% confidence interval 0.51 to 0.69; P < 0.0001). Among patients who underwent a renal transplant, there was no significant difference in the likelihood of graft failure between black and white patients, even after adjustment for comorbidities and socioeconomic status; black patients, however, had significantly lower posttransplantation mortality compared with white patients (hazard ratio 0.49; 95% confidence interval 0.28 to 0.88; P = 0.02). In conclusion, graft outcomes between black and white Canadian renal transplant patients are similar. Because this differs from the experience reported from the United States, further direct comparisons between the two populations is warranted.
引用
收藏
页码:172 / 179
页数:8
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