Heteromeric connexons in lens gap junction channels

被引：222
作者：
Jiang, JX
Goodenough, DA
机构：
[1] Department of Cell Biology, Harvard Medical School, Boston
来源：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1996年 / 93卷 / 03期
关键词：
D O I：
10.1073/pnas.93.3.1287
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Gap junction channels are formed by paired oligomeric membrane hemichannels called connexons, which are composed of proteins of the connexin family. Experiments with transfected cell lines and paired Xenopus oocytes have demonstrated that heterotypic intercellular channels which are formed by two connexons, each composed of a different connexin, can selectively occur. Studies by Stauffer [Stauffer, K. A. (1995) J. Biol, Chem. 270, 6768-6772] have shown that recombinant Cx26 and Cx32 coinfected into insect cells may form heteromeric connexons. By solubilizing and subfraction-immunoprecipitation that connexons can contain two different connexins forming heteromeric assemblies in vivo.
引用
收藏
页码：1287 / 1291
页数：5
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