No Association Between General Cognitive Ability and Rare Copy Number Variation

被引：13

作者：

McRae, Allan F. ^{[1
,2
]}

Wright, Margaret J. ^{[2
]}

Hansell, Narelle K. ^{[2
]}

Montgomery, Grant W. ^{[2
]}

Martin, Nicholas G. ^{[2
]}

机构：

[1] Univ Queensland, Diamantina Inst, Brisbane, Qld, Australia

[2] Queensland Inst Med Res, Brisbane, Qld 4006, Australia

来源：

BEHAVIOR GENETICS | 2013年 / 43卷 / 03期

基金：

澳大利亚研究理事会; 澳大利亚国家健康与医学研究理事会; 英国医学研究理事会;

关键词：

Intelligence; Copy-number variation; Genetic burden; Association; INTELLIGENCE; VARIANTS; MAP;

D O I：

10.1007/s10519-013-9587-9

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

There is increasing evidence for the role of rare copy-number variation (CNV) in the development of neuropsychiatric disorders. It is likely that such variants also have an effect on the variation of cognition in what is considered the "normal" phenotypic range. The role of rare CNV (> 20 KB in length; frequency < 5 %) on general cognitive ability is investigated in a sample of 800 individuals (mean age = 16.5, SD = 1.2) using copy-number variants called from the Illumina 610K SNP genotyping array with the software QuantiSNP. We assessed three measures of CNV burden-total CNV length, number of CNV and average CNV length-for both deletions and duplications in combination and separately. No correlation was found between any of the measures of CNV burden and IQ, or when comparing the top and bottom 10 % of the sample for IQ, both on a genome-wide scale and at individual positions across the genome.

引用

页码：202 / 207

页数：6

共 26 条

[11] Recurrent Rearrangements in Synaptic and Neurodevelopmental Genes and Shared Biologic Pathways in Schizophrenia, Autism, and Mental Retardation [J].

Guilmatre, Audrey ;

Dubourg, Christele ;

Mosca, Anne-Laure ;

Legallic, Solenn ;

Goldenberg, Alice ;

Drouin-Garraud, Valerie ;

Layet, Valerie ;

Rosier, Antoine ;

Briault, Sylvain ;

Bonnet-Brilhault, Frederique ;

Laumonnier, Frederic ;

Odent, Sylvie ;

Le Vacon, Gael ;

Joly-Helas, Geraldine ;

David, Veronique ;

Bendavid, Claude ;

Pinoit, Jean-Michel ;

Henry, Celine ;

Impallomeni, Caterina ;

Germano, Eva ;

Tortorella, Gaetano ;

Di Rosa, Gabriella ;

Barthelemy, Catherine ;

Andres, Christian ;

Faivre, Laurence ;

Frebourg, Thierry ;

Veber, Pascale Saugier ;

Campion, Dominique .

ARCHIVES OF GENERAL PSYCHIATRY, 2009, 66 (09) :947-+

[12]

Jackson D.N., 1998, MULTIDIMENSIONAL APT

[13] De novo CNV analysis implicates specific abnormalities of postsynaptic signalling complexes in the pathogenesis of schizophrenia [J].

Kirov, G. ;

Pocklington, A. J. ;

Holmans, P. ;

Ivanov, D. ;

Ikeda, M. ;

Ruderfer, D. ;

Moran, J. ;

Chambert, K. ;

Toncheva, D. ;

Georgieva, L. ;

Grozeva, D. ;

Fjodorova, M. ;

Wollerton, R. ;

Rees, E. ;

Nikolov, I. ;

van de Lagemaat, L. N. ;

Bayes, A. ;

Fernandez, E. ;

Olason, P. I. ;

Boettcher, Y. ;

Komiyama, N. H. ;

Collins, M. O. ;

Choudhary, J. ;

Stefansson, K. ;

Stefansson, H. ;

Grant, S. G. N. ;

Purcell, S. ;

Sklar, P. ;

O'Donovan, M. C. ;

Owen, M. J. .

MOLECULAR PSYCHIATRY, 2012, 17 (02) :142-153

[14] A genetic investigation of the covariation among Inspection Time, Choice Reaction Time, and IQ subtest scores [J].

Luciano, M ;

Wright, MJ ;

Geffen, GM ;

Geffen, LB ;

Smith, GA ;

Martin, NG .

BEHAVIOR GENETICS, 2004, 34 (01) :41-50

[15] X-chromosome tiling path array detection of copy number variants in patients with chromosome X-linked mental retardation [J].

Madrigal, I. ;

Rodriguez-Revenga, L. ;

Armengol, L. ;

Gonzalez, E. ;

Rodriguez, B. ;

Badenas, C. ;

Sanchez, A. ;

Martinez, F. ;

Guitart, M. ;

Fernandez, I. ;

Arranz, J. A. ;

Tejada, M. I. ;

Perez-Jurado, L. A. ;

Estivill, X. ;

Mila, M. .

BMC GENOMICS, 2007, 8

[16] Common Variants in the Trichohyalin Gene Are Associated with Straight Hair in Europeans [J].

Medland, Sarah E. ;

Nyholt, Dale R. ;

Painter, Jodie N. ;

McEvoy, Brian P. ;

McRae, Allan F. ;

Zhu, Gu ;

Gordon, Scott D. ;

Ferreira, Manuel A. R. ;

Wright, Margaret J. ;

Henders, Anjali K. ;

Campbell, Megan J. ;

Duffy, David L. ;

Hansell, Narelle K. ;

Macgregor, Stuart ;

Slutske, Wendy S. ;

Heath, Andrew C. ;

Montgomery, Grant W. ;

Martin, Nicholas G. .

AMERICAN JOURNAL OF HUMAN GENETICS, 2009, 85 (05) :750-755

[17] Genome-wide survey implicates the influence of copy number variants (CNVs) in the development of early-onset bipolar disorder [J].

Priebe, L. ;

Degenhardt, F. A. ;

Herms, S. ;

Haenisch, B. ;

Mattheisen, M. ;

Nieratschker, V. ;

Weingarten, M. ;

Witt, S. ;

Breuer, R. ;

Paul, T. ;

Alblas, M. ;

Moebus, S. ;

Lathrop, M. ;

Leboyer, M. ;

Schreiber, S. ;

Grigoroiu-Serbanescu, M. ;

Maier, W. ;

Propping, P. ;

Rietschel, M. ;

Noethen, M. M. ;

Cichon, S. ;

Muehleisen, T. W. .

MOLECULAR PSYCHIATRY, 2012, 17 (04) :421-432

[18] PLINK: A tool set for whole-genome association and population-based linkage analyses [J].

Purcell, Shaun ;

Neale, Benjamin ;

Todd-Brown, Kathe ;

Thomas, Lori ;

Ferreira, Manuel A. R. ;

Bender, David ;

Maller, Julian ;

Sklar, Pamela ;

de Bakker, Paul I. W. ;

Daly, Mark J. ;

Sham, Pak C. .

AMERICAN JOURNAL OF HUMAN GENETICS, 2007, 81 (03) :559-575

[19] X-linked mental retardation [J].

Ropers, HH ;

Hamel, BCJ .

NATURE REVIEWS GENETICS, 2005, 6 (01) :46-57

[20] Strong association of de novo copy number mutations with autism [J].

Sebat, Jonathan ;

Lakshmi, B. ;

Malhotra, Dheeraj ;

Troge, Jennifer ;

Lese-Martin, Christa ;

Walsh, Tom ;

Yamrom, Boris ;

Yoon, Seungtai ;

Krasnitz, Alex ;

Kendall, Jude ;

Leotta, Anthony ;

Pai, Deepa ;

Zhang, Ray ;

Lee, Yoon-Ha ;

Hicks, James ;

Spence, Sarah J. ;

Lee, Annette T. ;

Puura, Kaija ;

Lehtimaeki, Terho ;

Ledbetter, David ;

Gregersen, Peter K. ;

Bregman, Joel ;

Sutcliffe, James S. ;

Jobanputra, Vaidehi ;

Chung, Wendy ;

Warburton, Dorothy ;

King, Mary-Claire ;

Skuse, David ;

Geschwind, Daniel H. ;

Gilliam, T. Conrad ;

Ye, Kenny ;

Wigler, Michael .

SCIENCE, 2007, 316 (5823) :445-449

← 1 2 3 →