共 41 条
Molecular Monitoring of BCR-ABL Transcripts after Allogeneic Stem Cell Transplantation for Chronic Myeloid Leukemia
被引:25
作者:

Arpinati, Mario
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Univ Bologna, Dept Hematol & Oncol Sci Seragnoli, I-40138 Bologna, Italy Univ Bologna, Dept Hematol & Oncol Sci Seragnoli, I-40138 Bologna, Italy

Tolomelli, Giulia
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Univ Bologna, Dept Hematol & Oncol Sci Seragnoli, I-40138 Bologna, Italy Univ Bologna, Dept Hematol & Oncol Sci Seragnoli, I-40138 Bologna, Italy

Bochicchio, Maria Teresa
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Univ Bologna, Dept Hematol & Oncol Sci Seragnoli, I-40138 Bologna, Italy Univ Bologna, Dept Hematol & Oncol Sci Seragnoli, I-40138 Bologna, Italy

Castagnetti, Fausto
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Univ Bologna, Dept Hematol & Oncol Sci Seragnoli, I-40138 Bologna, Italy Univ Bologna, Dept Hematol & Oncol Sci Seragnoli, I-40138 Bologna, Italy

Amabile, Marilina
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Univ Bologna, Dept Hematol & Oncol Sci Seragnoli, I-40138 Bologna, Italy Univ Bologna, Dept Hematol & Oncol Sci Seragnoli, I-40138 Bologna, Italy

Bandini, Giuseppe
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Univ Bologna, Dept Hematol & Oncol Sci Seragnoli, I-40138 Bologna, Italy Univ Bologna, Dept Hematol & Oncol Sci Seragnoli, I-40138 Bologna, Italy

Bonifazi, Francesca
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Univ Bologna, Dept Hematol & Oncol Sci Seragnoli, I-40138 Bologna, Italy Univ Bologna, Dept Hematol & Oncol Sci Seragnoli, I-40138 Bologna, Italy

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Rosti, Gianantonio
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Univ Bologna, Dept Hematol & Oncol Sci Seragnoli, I-40138 Bologna, Italy Univ Bologna, Dept Hematol & Oncol Sci Seragnoli, I-40138 Bologna, Italy

Martinelli, Giovanni
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Univ Bologna, Dept Hematol & Oncol Sci Seragnoli, I-40138 Bologna, Italy Univ Bologna, Dept Hematol & Oncol Sci Seragnoli, I-40138 Bologna, Italy

Baccarani, Michele
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h-index: 0
机构:
Univ Bologna, Dept Hematol & Oncol Sci Seragnoli, I-40138 Bologna, Italy Univ Bologna, Dept Hematol & Oncol Sci Seragnoli, I-40138 Bologna, Italy
机构:
[1] Univ Bologna, Dept Hematol & Oncol Sci Seragnoli, I-40138 Bologna, Italy
关键词:
Allogeneic hematopoietic stem cell transplantation (HSCT);
Chronic myeloid leukemia (CML);
BCR-ABL;
Minimal residual disease (MRD);
BONE-MARROW-TRANSPLANTATION;
CHRONIC MYELOGENOUS LEUKEMIA;
MINIMAL RESIDUAL DISEASE;
INTERFERON-ALPHA THERAPY;
VERSUS-HOST-DISEASE;
QUANTITATIVE RT-PCR;
CYTOGENETIC REMISSION;
PERIPHERAL-BLOOD;
RELAPSE;
CML;
D O I:
10.1016/j.bbmt.2013.01.007
中图分类号:
R5 [内科学];
学科分类号:
1002 ;
100201 ;
摘要:
The monitoring of minimal residual disease (MRD) through low sensitivity real-time (RT) polymerase chain reaction (PCR) analysis of BCR-ABL transcripts allows early detection of chronic myeloid leukemia (CML) relapse after allogeneic hematopoietic stem cell transplantation (HSCT). The introduction of more sensitive techniques, such as RT quantitative (Q)-PCR, may lead to an overestimation of the risk of CML relapse. In this study, we reviewed the results of peripheral blood RT Q-PCR in CML patients who underwent allogeneic HSCT from 1983 to 2007. In our laboratory, RT Q-PCR analysis was routinely performed since 2002. Eighty-seven of 189 patients had available RT Q-PCR data; 63 patients had at least 3 RT Q-PCR analyses assessable. Fifty-two of 63 patients (83%) had, at least once, detectable transcript levels, but with an BCR-ABL/ABL ratio <.1% defined as <MR3 (molecular remission <0,1%), whereas 11 (17%) had persistent undetectable BCR-ABL transcripts. Six of 52 patients with <MR3 relapsed, defined as BCR-ABL transcript numbers >.1% confirmed by the finding of Ph+ cells in bone marrow. No patients with persistent undetectable transcripts relapsed (P = .19). Relapse did not correlate with the number of occurrences of <MR3 or with the time to the first <MR3 result. Finally, of 46 patients with detectable transcripts who did not relapse, 35 had undetectable transcripts at last contact. RT Q-PCR analysis had low specificity (19%) and low positive predictive value (12%) in predicting relapse of CML patients after allogeneic HSCf. Our data suggest that detection of low BCR-ABL transcript levels by RT Q-PCR analysis has a poor accuracy in defining the risk of CML relapse and should not be considered as the unique indication to treatment. Fluctuation of BCR-ABL transcripts levels is common as late as >= 10 years post-transplantation, possibly suggesting the long-term persistence of CML stem cells. (C) 2013 American Society for Blood and Marrow Transplantation.
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页码:735 / 740
页数:6
相关论文
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机构: Univ Heidelberg, Fak Klin Med Mannheim, Med Klin 3, D-68305 Mannheim, Germany

Wittor, H
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h-index: 0
机构: Univ Heidelberg, Fak Klin Med Mannheim, Med Klin 3, D-68305 Mannheim, Germany

Weisser, A
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h-index: 0
机构: Univ Heidelberg, Fak Klin Med Mannheim, Med Klin 3, D-68305 Mannheim, Germany

Reiter, A
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机构: Univ Heidelberg, Fak Klin Med Mannheim, Med Klin 3, D-68305 Mannheim, Germany

Willer, A
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机构: Univ Heidelberg, Fak Klin Med Mannheim, Med Klin 3, D-68305 Mannheim, Germany

Berger, U
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机构: Univ Heidelberg, Fak Klin Med Mannheim, Med Klin 3, D-68305 Mannheim, Germany

Hehlmann, R
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机构: Univ Heidelberg, Fak Klin Med Mannheim, Med Klin 3, D-68305 Mannheim, Germany

Cross, NCP
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机构: Univ Heidelberg, Fak Klin Med Mannheim, Med Klin 3, D-68305 Mannheim, Germany

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[10]
Standardization and quality control studies of 'real-time' quantitative reverse transcriptase polymerase chain reaction of fusion gene transcripts for residual disease detection in leukemia -: A Europe Against Cancer Program
[J].
Gabert, J
;
Beillard, E
;
van der Velden, VHJ
;
Bi, W
;
Grimwade, D
;
Pallisgaard, N
;
Barbany, G
;
Cazzaniga, G
;
Cayuela, JM
;
Cavé, H
;
Pane, F
;
Aerts, JLE
;
De Micheli, D
;
Thirion, X
;
Pradel, V
;
González, M
;
Viehmann, S
;
Malec, M
;
Saglio, G
;
van Dongen, JJM
.
LEUKEMIA,
2003, 17 (12)
:2318-2357

Gabert, J
论文数: 0 引用数: 0
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机构: Inst J Paoli I Calmettes, Dept Hematol Biol, Marseille, France

Beillard, E
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h-index: 0
机构: Inst J Paoli I Calmettes, Dept Hematol Biol, Marseille, France

van der Velden, VHJ
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h-index: 0
机构: Inst J Paoli I Calmettes, Dept Hematol Biol, Marseille, France

Bi, W
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h-index: 0
机构: Inst J Paoli I Calmettes, Dept Hematol Biol, Marseille, France

Grimwade, D
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h-index: 0
机构: Inst J Paoli I Calmettes, Dept Hematol Biol, Marseille, France

Pallisgaard, N
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h-index: 0
机构: Inst J Paoli I Calmettes, Dept Hematol Biol, Marseille, France

Barbany, G
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h-index: 0
机构: Inst J Paoli I Calmettes, Dept Hematol Biol, Marseille, France

Cazzaniga, G
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h-index: 0
机构: Inst J Paoli I Calmettes, Dept Hematol Biol, Marseille, France

Cayuela, JM
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h-index: 0
机构: Inst J Paoli I Calmettes, Dept Hematol Biol, Marseille, France

Cavé, H
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机构: Inst J Paoli I Calmettes, Dept Hematol Biol, Marseille, France

Pane, F
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机构: Inst J Paoli I Calmettes, Dept Hematol Biol, Marseille, France

Aerts, JLE
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机构: Inst J Paoli I Calmettes, Dept Hematol Biol, Marseille, France

De Micheli, D
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机构: Inst J Paoli I Calmettes, Dept Hematol Biol, Marseille, France

Thirion, X
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机构: Inst J Paoli I Calmettes, Dept Hematol Biol, Marseille, France

Pradel, V
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h-index: 0
机构: Inst J Paoli I Calmettes, Dept Hematol Biol, Marseille, France

González, M
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h-index: 0
机构: Inst J Paoli I Calmettes, Dept Hematol Biol, Marseille, France

Viehmann, S
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机构: Inst J Paoli I Calmettes, Dept Hematol Biol, Marseille, France

Malec, M
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h-index: 0
机构: Inst J Paoli I Calmettes, Dept Hematol Biol, Marseille, France

Saglio, G
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h-index: 0
机构: Inst J Paoli I Calmettes, Dept Hematol Biol, Marseille, France

van Dongen, JJM
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机构: Inst J Paoli I Calmettes, Dept Hematol Biol, Marseille, France