pH-sensitive poly( glutamic acid) grafted mesoporous silica nanoparticles for drug delivery

被引：67
作者：
Zheng, Jin [1 ,2 ]
Tian, Xuejiao [1 ,2 ]
Sun, Yangfei [3 ,4 ]
Lu, Daru [3 ,4 ]
Yang, Wuli [1 ,2 ]
机构：
[1] Fudan Univ, State Key Lab Mol Engn Polymers, Shanghai 200433, Peoples R China
[2] Fudan Univ, Dept Macromol Sci, Shanghai 200433, Peoples R China
[3] Fudan Univ, State Key Lab Genet Engn, Shanghai 200433, Peoples R China
[4] Fudan Univ, Sch Life Sci, Shanghai 200433, Peoples R China
来源：
INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2013年 / 450卷 / 1-2期
基金：
美国国家科学基金会;
关键词：
Mesoporous silica nanoparticle; pH; sensitive; Poly(L glimaticlutamic acid); Drug delivery; DOX; POLY(L-GLUTAMIC ACID); CONTROLLED-RELEASE; GUEST MOLECULES; SYSTEM; BIOCOMPATIBILITY; NANOVALVES; COPOLYMER; VESICLES; CARRIER; CELLS;
D O I：
10.1016/j.ijpharm.2013.04.014
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
pH-(sensitive poly(L-(glutamic acid) grafted mesoporous silica nanoparticles (MSN-(PLGA) were prepared by the surface-(initiated N-(carboxyanhydride polymerization method. The resultant MSN-(PLGA was well dispersed in aqueous medium and showed high drug loading efficiency, superior stability, and significantly higher drug release rates. The cumulative release of doxorubicin hydrochloride (DOX) from DOX-(loaded MSN-(PLGA (DOX@ MSN-(PLGA) was pH-(dependent and the release rate was much higher at pH 5.5 than that at pH 7.4. The cytotoxicity results indicated that the blank MSN-(PLGA was biocompatible and the DOX@ MSN-(PLGA had potent in vitro cytotoxicity effect similar to free DOX. Overall, these results demonstrate that MSN-(PLGA is a promising platform to build pH controlled drug delivery systems for cancer therapy. (C) 2013 Elsevier B.V. All rights reserved.
引用
收藏
页码：296 / 303
页数：8
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