pH-sensitive poly( glutamic acid) grafted mesoporous silica nanoparticles for drug delivery

被引：68
|
作者：
Zheng, Jin [1 ,2 ]
Tian, Xuejiao [1 ,2 ]
Sun, Yangfei [3 ,4 ]
Lu, Daru [3 ,4 ]
Yang, Wuli [1 ,2 ]
机构：
[1] Fudan Univ, State Key Lab Mol Engn Polymers, Shanghai 200433, Peoples R China
[2] Fudan Univ, Dept Macromol Sci, Shanghai 200433, Peoples R China
[3] Fudan Univ, State Key Lab Genet Engn, Shanghai 200433, Peoples R China
[4] Fudan Univ, Sch Life Sci, Shanghai 200433, Peoples R China
来源：
INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2013年 / 450卷 / 1-2期
基金：
美国国家科学基金会;
关键词：
Mesoporous silica nanoparticle; pH; sensitive; Poly(L glimaticlutamic acid); Drug delivery; DOX; POLY(L-GLUTAMIC ACID); CONTROLLED-RELEASE; GUEST MOLECULES; SYSTEM; BIOCOMPATIBILITY; NANOVALVES; COPOLYMER; VESICLES; CARRIER; CELLS;
D O I：
10.1016/j.ijpharm.2013.04.014
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
pH-(sensitive poly(L-(glutamic acid) grafted mesoporous silica nanoparticles (MSN-(PLGA) were prepared by the surface-(initiated N-(carboxyanhydride polymerization method. The resultant MSN-(PLGA was well dispersed in aqueous medium and showed high drug loading efficiency, superior stability, and significantly higher drug release rates. The cumulative release of doxorubicin hydrochloride (DOX) from DOX-(loaded MSN-(PLGA (DOX@ MSN-(PLGA) was pH-(dependent and the release rate was much higher at pH 5.5 than that at pH 7.4. The cytotoxicity results indicated that the blank MSN-(PLGA was biocompatible and the DOX@ MSN-(PLGA had potent in vitro cytotoxicity effect similar to free DOX. Overall, these results demonstrate that MSN-(PLGA is a promising platform to build pH controlled drug delivery systems for cancer therapy. (C) 2013 Elsevier B.V. All rights reserved.
引用
收藏
页码：296 / 303
页数：8
相关论文
共 50 条
  • [41] Folic acid-grafted poly-3-hydroxybutyrate nanoparticles for enhanced pH-sensitive paclitaxel delivery and cancer cell targeting
    Aslam, Aqsa
    Perveen, Kousar
    Berger, Martin R.
    Zepp, Michael
    Klika, Karel D.
    Hameed, Abdul
    Masood, Farha
    COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 2025, 710
  • [42] Magnetic mesoporous silica nanoparticles functionalized by pH-sensitive caps for DOX release
    Sayna Shahmoradi
    Morteza Bahram
    Fariba Hoseinpour
    Journal of the Iranian Chemical Society, 2019, 16 : 1801 - 1808
  • [43] Magnetic mesoporous silica nanoparticles functionalized by pH-sensitive caps for DOX release
    Shahmoradi, Sayna
    Bahram, Morteza
    Hoseinpour, Fariba
    JOURNAL OF THE IRANIAN CHEMICAL SOCIETY, 2019, 16 (08) : 1801 - 1808
  • [44] Silica-chitosan nanocomposite mediated pH-sensitive drug delivery
    Gaware, Shankar A.
    Rokade, Kasturi A.
    Kale, S. N.
    JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 2019, 49 : 345 - 351
  • [45] pH-Sensitive mesoporous silica nanoparticles for chemo-photodynamic combination therapy
    Yan, Tingsheng
    Cheng, Jinju
    Liu, Zongjun
    Cheng, Feng
    Wei, Xinjing
    He, Jinmei
    COLLOIDS AND SURFACES B-BIOINTERFACES, 2018, 161 : 442 - 448
  • [46] pH-sensitive nanoparticles of poly(amino acid) dodecanoate complexes
    General, S
    Thünemann, AF
    INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2001, 230 (1-2) : 11 - 24
  • [47] Mesoporous Silica Nanoparticles with pH-Sensitive Nanovalves for Delivery of Moxifloxacin Provide Improved Treatment of Lethal Pneumonic Tularemia
    Li, Zilu
    Clemens, Daniel L.
    Lee, Bai-Yu
    Dillon, Barbara Jane
    Horwitz, Marcus A.
    Zink, Jeffrey I.
    ACS NANO, 2015, 9 (11) : 10778 - 10789
  • [48] Microfluidic-Assisted Fabrication of Dual-Coated pH-Sensitive Mesoporous Silica Nanoparticles for Protein Delivery
    Kucukturkmen, Berrin
    Inam, Wali
    Howaili, Fadak
    Gouda, Mariam
    Prabhakar, Neeraj
    Zhang, Hongbo
    Rosenholm, Jessica M.
    BIOSENSORS-BASEL, 2022, 12 (03):
  • [49] pH-Sensitive Biomaterials for Drug Delivery
    Zhuo, Shijie
    Zhang, Feng
    Yu, Junyu
    Zhang, Xican
    Yang, Guangbao
    Liu, Xiaowen
    MOLECULES, 2020, 25 (23):
  • [50] Janus Silver-Mesoporous Silica Nanocarriers for SERS Traceable and pH-Sensitive Drug Delivery in Cancer Therapy
    Shao, Dan
    Zhang, Xin
    Liu, Wenliang
    Zhang, Fan
    Zheng, Xiao
    Qiao, Ping
    Li, Jing
    Dong, Wen-fei
    Chen, Li
    ACS APPLIED MATERIALS & INTERFACES, 2016, 8 (07) : 4303 - 4308
12345