The androgen receptor gene mutations database

被引：46

作者：

Gottlieb, B

Trifiro, M

Lumbroso, R

Pinsky, L

机构：

[1] MCGILL UNIV, DEPT MED, MONTREAL, PQ H3T 1E2, CANADA

[2] MCGILL UNIV, DEPT BIOL, MONTREAL, PQ H3T 1E2, CANADA

[3] MCGILL UNIV, DEPT HUMAN GENET, MONTREAL, PQ H3T 1E2, CANADA

[4] JOHN ABBOTT COLL, DEPT BIOL, Ste Anne De Bellevue, PQ H9X 3L9, CANADA

来源：

NUCLEIC ACIDS RESEARCH | 1997年 / 25卷 / 01期

关键词：

D O I：

10.1093/nar/25.1.158

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The current version of the androgen receptor (AR) gene mutations database is described. The total number of reported mutations has risen from 212 to 272. We have expanded the database: (i) by adding a large amount of new data on somatic mutations in prostatic cancer tissue; (ii) by defining a new constitutional phenotype, mild androgen insensitivity (MAI); (iii) by placing additional relevant information on an internet site (http://www.mcgill.ca/androgendb/). The database has allowed us to examine the contribution of CpG sites to the multiplicity of reports of the same mutation in different families. The database is also available from EMBL (ftp.ebi.ac.uk/pub/databases/androgen) or as a Macintosh Filemaker Pro or Word file (MC33@musica,mcgill.ca).

引用

页码：158 / 162

页数：5

共 28 条

[1] ANDROGEN RECEPTOR GENE-MUTATIONS IDENTIFIED BY SSCP IN 14 SUBJECTS WITH ANDROGEN INSENSITIVITY SYNDROME [J].

BATCH, JA ;

WILLIAMS, DM ;

DAVIES, HR ;

BROWN, BD ;

EVANS, BAJ ;

HUGHES, IA ;

PATTERSON, MN .

HUMAN MOLECULAR GENETICS, 1992, 1 (07) :497-503

[2] ANDROGEN RECEPTOR MUTATIONS [J].

BRINKMANN, AO ;

JENSTER, G ;

RISSTALPERS, C ;

VANDERKORPUT, JAGM ;

BRUGGENWIRTH, HT ;

BOEHMER, ALM ;

TRAPMAN, J .

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 1995, 53 (1-6) :443-448

[3] STRUCTURAL-ANALYSIS OF COMPLEMENTARY-DNA AND AMINO-ACID SEQUENCES OF HUMAN AND RAT ANDROGEN RECEPTORS [J].

CHANG, CS ;

KOKONTIS, J ;

LIAO, SS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (19) :7211-7215

[4] MUTANT ANDROGEN RECEPTOR DETECTED IN AN ADVANCED-STAGE PROSTATIC-CARCINOMA IS ACTIVATED BY ADRENAL ANDROGENS AND PROGESTERONE [J].

CULIG, Z ;

HOBISCH, A ;

CRONAUER, MV ;

CATO, ACB ;

HITTMAIR, A ;

RADMAYR, C ;

EBERLE, J ;

BARTSCH, G ;

KLOCKER, H .

MOLECULAR ENDOCRINOLOGY, 1993, 7 (12) :1541-1550

[5] MUTATED HUMAN ANDROGEN RECEPTOR GENE DETECTED IN A PROSTATIC-CANCER PATIENT IS ALSO ACTIVATED BY ESTRADIOL [J].

ELO, JP ;

KVIST, L ;

LEINONEN, K ;

ISOMAA, V ;

HENTTU, P ;

LUKKARINEN, O ;

VIHKO, P .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1995, 80 (12) :3494-3500

[6]

Evans BAJ, 1996, PROSTATE, V28, P162, DOI 10.1002/(SICI)1097-0045(199603)28:3<162::AID-PROS3>3.0.CO

[7]

2-H

[8]

GADDIPATI JP, 1994, CANCER RES, V54, P2861

[9] The androgen receptor gene mutations database [J].

Gottlieb, B ;

Trifiro, M ;

Lumbroso, R ;

Vasiliou, DM ;

Pinsky, L .

NUCLEIC ACIDS RESEARCH, 1996, 24 (01) :151-154

[10] DETECTION OF POINT MUTATIONS IN THE ANDROGEN RECEPTOR GENE USING NONISOTOPIC SINGLE-STRAND CONFORMATION POLYMORPHISM ANALYSIS [J].

HIORT, O ;

WODTKE, A ;

STRUVE, D ;

ZOLLNER, A ;

SINNECKER, GHG ;

ALBERS, N ;

BEYE, M ;

BEYER, P ;

BIRR, C ;

BLUNCK, W ;

BRACK, C ;

BRAMSWIG, J ;

DORR, HG ;

GAL, A ;

HECKER, W ;

HEIDEMANN, P ;

HEINRICH, U ;

HEISE, HR ;

HESSE, V ;

HINKEL, M ;

HOEPFFNER, W ;

HOLDER, M ;

KEIM, L ;

KLASEN, M ;

KORSCH, E ;

KRUGER, G ;

LANDENDORFER, W ;

MIX, M ;

MORLOT, M ;

MUHLENBERG, R ;

OTTEN, A ;

PARTSCH, CJ ;

PELZ, L ;

VONPETRYKOWSKI, W ;

RABL, W ;

REICH, H ;

SCHENK, B ;

SCHNABEL, D ;

SIPPELL, W .

HUMAN MOLECULAR GENETICS, 1994, 3 (07) :1163-1166

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