Comprehensive analysis of the expression and prognosis for CDCAs in head and neck squamous cell carcinoma

Head and neck squamous cell carcinoma (HNSCC), a tumor included oral cavity, lips, larynx, oropharynx, and the nasopharynx et al. The cell division cycle-associated (CDCA) protein family (CDCA1-8) critical for normal cell function and cancer cell proliferation. We explored the mutation signatures and expression levels of variousCDCAsin detail in HNSCC. A comprehensive bioinformatics analysis pipeline based on copy number and gene expressions data from patients with HNSCC in order to given new insights into the possible functions and distinct prognostics that underlieCDCAsregulation. We compared the transcriptional expression ofCDCAsin HNSCC and found significantly elevated mRNA expression ofCDCA1-8in HNSCC tissues across multiple datasets. We also foundCDCA5/6/8are over-expressed both transcriptionally and translationally in patients with HNSCC. Our results suggested that that mRNA levels ofCDCA1/2/4/7related to the prognosis and can be used as a new useful biomarker for predicting the survival of HNSCC patients. The top 5CDCAsneighboring gene alterations in HNSCCs were found inMYC,STAG1,RAD21,KLHL9andNDC80. Multivariable Cox proportional hazard model also showed that CD8+ T cells were higher (P<0.05) in HNSCC-HPV-pos patients and that this was related toCDCA1/2/3/4/5/7. This study utilizes online tools to conduct specific gene analyses from free open databases, but our study requires more large-scale genomics research and basic research.