4-Formyl-Pyrazole-3-Carboxylate: A Useful Aldo-X Bifunctional Precursor for the Syntheses of Pyrazole-fused/Substituted Frameworks

被引：40

作者：

Devi, Nisha ^{[1
]}

Shankar, Ravi ^{[2
]}

Singh, Virender ^{[1
]}

机构：

[1] Dr BR Ambedkar Natl Inst Technol, Dept Chem, Jalandhar 144011, India

[2] CSIR Indian Inst Integrat Med, Bioorgan Chem Div, Jammu 180001, India

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2018年 / 55卷 / 02期

关键词：

1,3-DIPOLAR CYCLOADDITION REACTIONS; INFLAMMATORY-ANTIMICROBIAL AGENTS; O-ALKYNYL ALDEHYDES; ONE-POT SYNTHESIS; BIOLOGICAL EVALUATION; BETA-CARBOLINE; NITRILIMINE CYCLOADDITION; REGIOSELECTIVE SYNTHESIS; HETEROGENEOUS CATALYST; MOLECULAR HYBRIDS;

D O I：

10.1002/jhet.3045

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Pyrazole, a privileged class of heterocyclic compounds, constitute an interesting template for medicinal chemistry and is represented by several commercial drugs like Sildenafil, Zometapin, Celebrex, and Rimonabant. The presence of two functionalities with different reactivity in pyrazole moiety may open new avenues for insertion of diversity in pyrazole frameworks which may be of high medicinal significance. Ethyl 4-formyl-1H-pyrazole-3-carboxylate is a potential Aldo-X bifunctional building block (AXB3) which may be explored for generating complex pyrazole based molecular frameworks by using various organic transformations. The present manuscript is assimilation of literature pertaining to the synthesis and application of ethyl 4-formyl-1H-pyrazole-3-carboxylates and similar AXB3 for the development of pyrazole substituted and fused derivatives.

引用

页码：373 / 390

页数：18

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