A new naphthoquinone analogue and antiviral constituents from the root of Rhinacanthus nasutus

被引：24

作者：

Tran Minh Ngoc ^{[1
]}

Nguyen Thi Thanh Phuong ^{[1
]}

Nguyen Minh Khoi ^{[1
]}

Park, SeonJu ^{[2
]}

Kwak, Hee Jae ^{[2
]}

Nguyen Xuan Nhiem ^{[3
]}

Bui Thi Thu Trang ^{[4
]}

Bui Huu Tai ^{[3
]}

Song, Jae-Hyoung ^{[5
]}

Ko, Hyun-Jeong ^{[5
]}

Kim, Seung Hyun ^{[2
]}

机构：

[1] Natl Inst Med Mat, Hanoi, Vietnam

[2] Yonsei Univ, Yonsei Inst Pharmaceut Sci, Coll Pharm, Incheon, South Korea

[3] Vietnam Acad Sci & Technol, Inst Marine Biochem, Hanoi, Vietnam

[4] Hanoi Univ Ind, Hanoi, Vietnam

[5] Kangwon Natl Univ, Coll Pharm, Chunchon, South Korea

来源：

NATURAL PRODUCT RESEARCH | 2019年 / 33卷 / 03期

基金：

新加坡国家研究基金会;

关键词：

Rhinacasutone; rhinacanthin; Rhinacanthus nasutus; antivirus; LIGNANS; VIRUS;

D O I：

10.1080/14786419.2018.1452004

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Rhinacanthus nasutus (L.) Kurz (Acanthaceae) is known as traditional medicine for the treatment of fungal and herpes virus infections. A new naphthoquinone racemate, rhinacasutone (1) together with seven known compounds, rhinacanthone (2), rhinacanthins C, D, N, Q, and E (3-7), and heliobuphthalmin (8) were isolated from root of R. nasutus. Their structures were determined on the basis of extensive spectroscopic methods, including 1D-, 2D-NMR and MS data. All the isolated compounds were tested for their antiviral activities against PR8, HRV1B, and CVB3-infected vero cells. Compounds 3-6 exhibited significant antiviral activities with the IC50 value ranging from 0.03 to 23.7 mu M in all three infections. [GRAPHICS] .

引用

页码：360 / 366

页数：7

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