Subtle progesterone rise on the day of human chorionic gonadotropin administration is associated with lower live birth rates in women undergoing assisted reproductive technology: a retrospective study with 2,555 fresh embryo transfers

被引：86
作者：
Ochsenkuen, Robert [1 ]
Arzberger, Andrea [1 ]
von Schoenfeldt, Viktoria [2 ]
Gallwas, Julia [2 ]
Rogenhofer, Nina [2 ]
Crispin, Alexander [3 ]
Thaler, Christian J. [2 ]
Noss, Ulrich [1 ]
机构：
[1] Ctr Reprod Med, D-80331 Munich, Germany
[2] Univ Munich, Dept Obstet & Gynecol, Munich, Germany
[3] Univ Munich, Dept Med Informat Biometry & Epidemiol, Munich, Germany
来源：
FERTILITY AND STERILITY | 2012年 / 98卷 / 02期
关键词：
IVF; pregnancy rate; progesterone; embryo transfer; GnRH agonist; IN-VITRO FERTILIZATION; ELEVATED SERUM PROGESTERONE; CONTROLLED OVARIAN HYPERSTIMULATION; INTRACYTOPLASMIC SPERM INJECTION; HIGHER PREGNANCY RATE; PREMATURE LUTEINIZATION; HORMONE AGONIST; INVITRO FERTILIZATION; PREDICT PREGNANCY; FOLLICULAR PHASE;
D O I：
10.1016/j.fertnstert.2012.04.041
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Objective: To evaluate the association between serum P levels on the day of hCG administration and pregnancy outcome in women undergoing controlled ovarian hyperstimulation, prevention of premature ovulation by GnRH analogues, and fresh ET after 5 days of embryo culture. Design: Retrospective, observational, cohort study. Setting: Private IVF center. Patient(s): A total of 2,555 women undergoing fresh ET on day 5 in 2,062 GnRH agonist and 493 GnRH antagonist cycles. Intervention(s): None. Main Outcome Measure(s): Live birth rate. Result(s): Live birth rate in cycles with GnRH agonists was significantly lower in women with P levels >= 2.0 ng/mL (17.4%) on the day of hCG administration as compared with women with P levels < 1.5 ng/mL (24.6%) and 1.5-1.99 ng/mL (26.7%). No such significant differences in live birth rates in cycles with GnRH antagonist could be observed. Conclusion(s): A rise of serum P levels >= 2.0 ng/mL on the day of hCG administration is associated with impaired early embryo implantation and reduced live birth rate in cycles with GnRH agonists after day-5 fresh ET. Clinical Trial Registration Number: NCT01426152. (Fertil Steril (R) 2012;98:347-54. (C) 2012 by American Society for Reproductive Medicine.)
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收藏
页码：347 / 354
页数：8
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