Lessons from Natural Products Chemistry Can Offer Novel Approaches for Synthetic Chemistry in Drug Discovery Miniperspective

被引:43
作者
Vasilevich, Natalya I. [1 ]
Kombarov, Roman V. [1 ]
Genis, Dmitry V. [1 ]
Kirpichenok, Michael A. [1 ]
机构
[1] Asinex, Moscow 125480, Russia
关键词
DIVERSITY;
D O I
10.1021/jm300344v
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
[No abstract available]
引用
收藏
页码:7003 / 7009
页数:7
相关论文
共 25 条
[11]   The evolving role of natural products in drug discovery [J].
Koehn, FE ;
Carter, GT .
NATURE REVIEWS DRUG DISCOVERY, 2005, 4 (03) :206-220
[12]   Macrocycles Are Great Cycles: Applications, Opportunities, and Challenges of Synthetic Macrocycles in Drug Discovery [J].
Marsault, Eric ;
Peterson, Mark L. .
JOURNAL OF MEDICINAL CHEMISTRY, 2011, 54 (07) :1961-2004
[13]   Synthesis of Natural-Product-Like Molecules with Over Eighty Distinct Scaffolds [J].
Morton, Daniel ;
Leach, Stuart ;
Cordier, Christopher ;
Warriner, Stuart ;
Nelson, Adam .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2009, 48 (01) :104-109
[14]   Synthesis of Skeletally Diverse Alkaloid-Like Small Molecules [J].
Murrison, Sarah ;
Maurya, Sushil K. ;
Einzinger, Christian ;
McKeever-Abbas, Ben ;
Warriner, Stuart ;
Nelson, Adam .
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2011, 2011 (12) :2354-2359
[15]  
Nicolaou KC, 2000, ANGEW CHEM INT EDIT, V39, P44
[16]   Macrolactonizations in the total synthesis of natural products [J].
Parenty, A ;
Moreau, X ;
Campagne, JM .
CHEMICAL REVIEWS, 2006, 106 (03) :911-939
[17]   The Medicinal Chemist's Toolbox: An Analysis of Reactions Used in the Pursuit of Drug Candidates [J].
Roughley, Stephen D. ;
Jordan, Allan M. .
JOURNAL OF MEDICINAL CHEMISTRY, 2011, 54 (10) :3451-3479
[18]   Target-oriented and diversity-oriented organic synthesis in drug discovery [J].
Schreiber, SL .
SCIENCE, 2000, 287 (5460) :1964-1969
[19]   ORGANIC CHEMISTRY Molecular diversity by design [J].
Schreiber, Stuart L. .
NATURE, 2009, 457 (7226) :153-154
[20]   Semipinacol Rearrangement in Natural Product Synthesis [J].
Song, Zhen-Lei ;
Fan, Chun-An ;
Tu, Yong-Qiang .
CHEMICAL REVIEWS, 2011, 111 (11) :7523-7556