Total Polyphenol Intake Is Inversely Associated with a Pro/Anti-Inflammatory Biomarker Ratio in European Adolescents of the HELENA Study

被引：14

作者：

Wisnuwardani, Ratih Wirapuspita ^{[1
,2
]}

De Henauw, Stefaan ^{[1
]}

Ferrari, Marika ^{[3
]}

Forsner, Maria ^{[4
,5
]}

Gottrand, Frederic ^{[6
]}

Huybrechts, Inge ^{[1
,7
]}

Kafatos, Antonios G. ^{[8
]}

Kersting, Mathilde ^{[9
]}

Knaze, Viktoria ^{[7
]}

Manios, Yannis ^{[10
]}

Marcos, Ascension ^{[11
]}

Molnar, Denes ^{[12
]}

Rothwell, Joseph A. ^{[7
]}

Ruperez, Azahara Iris ^{[13
]}

Scalbert, Augustin ^{[7
]}

Widhalm, Kurt ^{[14
]}

Moreno, Luis A. ^{[13
]}

Michels, Nathalie ^{[1
]}

机构：

[1] Univ Ghent, Fac Med & Hlth Sci, Dept Publ Hlth & Primary Care, Ghent, Belgium

[2] Mulawarman Univ, Fac Publ Hlth, Dept Publ Hlth Nutr, Samarinda, Indonesia

[3] CREA Res Ctr Food & Nutr, Rome, Italy

[4] Umea Univ, Dept Nursing, Umea, Sweden

[5] Dalarna Univ, Sch Educ Hlth & Social Sci, Falun, Sweden

[6] Univ Lille, CHU Lille, Inserm U995, Lille, France

[7] WHO, Int Agcy Res Canc, Lyon, France

[8] Univ Crete, Sch Med, Clin Nutr & Dis Prevent, Iraklion, Greece

[9] Ruhr Univ Bochum, Pediat Univ Clin, Res Dept Child Nutr, Bochum, Germany

[10] Harokopio Univ, Dept Nutr & Dietet, Athens, Greece

[11] Inst Food Sci Technol & Nutr, Dept Metab & Nutr, Immunonutr Res Grp, Madrid, Spain

[12] Univ Pecs, Med Sch, Dept Pediat, Pecs, Hungary

[13] Univ Zaragoza, Fac Hlth Sci, GENUD Growth Exercise Nutr & Dev Res Grp, Edificio SAI,C Pedro Cerbuna S-N, Zaragoza, Spain

[14] Med Univ Vienna, Dept Pediat, Div Clin Nutr, Vienna, Austria

来源：

JOURNAL OF NUTRITION | 2020年 / 150卷 / 06期

关键词：

polyphenol; flavonoid; youth; adolescent; proanthocyanidin; inflammation; cytokines; HEALTHY LIFE-STYLE; DIETARY POLYPHENOLS; OXIDATIVE STRESS; CYTOKINES; CONSUMPTION; POPULATION; MECHANISMS; NUTRITION; PROFILE; DAMAGE;

D O I：

10.1093/jn/nxaa064

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Background: Although high dietary polyphenol intake is negatively associated with risk of certain inflammation-associated chronic diseases, the underlying mechanisms are not fully understood and few studies have explored this in adolescents. Objective: This study aimed to evaluate the association between intakes of total polyphenols, polyphenol classes, and the 10 most commonly consumed individual polyphenols with inflammatory biomarkers in the blood of European adolescents. Methods: In the Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) Study, 526 adolescents (54% girls; 12.5-17.5 y) had data on inflammatory biomarkers and polyphenol intake from 2 nonconsecutive 24-h recalls via matching with the Phenol-Explorer database. Inflammatory biomarkers in serum were IL-1, IL-2, IL-4, IL-5, IL-6, IL-10, transforming growth factor beta 1 (TGF-beta 1), TNF-alpha, IFN-gamma, soluble vascular adhesion molecule 1 (sVCAM-1), soluble intercellular adhesion molecule 1 (sICAM-1), soluble E-selectin (sE-selectin), white blood cells, lymphocytes, T cells, and C-reactive protein. Multilevel linear models were used to test associations of polyphenol intake with a pro/anti-inflammatory biomarker ratio [(zTNF-alpha zIL-6 zIL-1)/3/zIL-10] as well as with separate inflammatory biomarkers, adjusted for sociodemographic variables, diet inflammation index, BMI z score, and serum triglycerides. Results: The pro/anti-inflammatory biomarker ratio was linearly inversely associated with the intake of total polyphenols (beta = -0.11, P = 0.040). When other inflammation biomarkers were considered, the serum IL-10 concentration was inversely associated with total polyphenol (beta = -0.12, P= 0.017) and flavonoid (beta = -0.12, P= 0.013) intakes, findings that were inconsistent with the biomarker ratio results. However, the anti-inflammatory capacity of polyphenols was confirmed by positive associations of IL-4 with phenolic acid (beta = 0.09 P= 0.049) and stilbene (beta = 0.13, P= 0.019) intakes and the negative association of IL-1, IL-2, and IFN-gamma with lignan intake (beta = -0.10, P = 0.034; beta = -0.09, P = 0.049; beta = -0.11, P = 0.023). Conclusions: The negative relation with the overall pro/anti-inflammatory biomarker ratio suggests a potential anti-inflammatory role of high polyphenol intakes among European adolescents. Nevertheless, associations are dependent on polyphenol type and the inflammatory biomarker measured.

引用

页码：1610 / 1618

页数：9

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