BUTYRYLCHOLINESTERASE-KNOCKOUT REDUCES BRAIN DEPOSITION OF FIBRILLAR β-AMYLOID IN AN ALZHEIMER MOUSE MODEL

被引：117
|
作者：
Reid, G. Andrew [1 ]
Darvesh, Sultan [1 ,2 ]
机构：
[1] Dalhousie Univ, Dept Med Neurosci, Halifax, NS, Canada
[2] Dalhousie Univ, Dept Med Neurol & Geriatr Med, Halifax, NS, Canada
来源：
NEUROSCIENCE | 2015年 / 298卷
基金：
加拿大健康研究院;
关键词：
Alzheimer's disease; beta-amyloid; butyrylcholinesterase; 5XFAD mouse; butyrylcholinesterase-knock-out; cholinergic system; K-VARIANT; SEX-DIFFERENCES; APOLIPOPROTEIN E4; NO ASSOCIATION; 3XTG-AD MICE; DISEASE; ESTROGEN; CHOLINESTERASES; DEMENTIA; GENES;
D O I：
10.1016/j.neuroscience.2015.04.039
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
In Alzheimer's disease (AD), numerous beta-amyloid (A beta) plaques are associated with butyrylcholinesterase (BChE) activity, the significance of which is unclear. A mouse model, containing five human familial AD genes (5XFAD), also develops A beta plaques with BChE activity. Knock-out of BChE in this model showed diminished fibrillar A beta plaque deposition, more so in males than females. This suggests that lack of BChE reduces deposition of fibrillar A beta in AD and this effect may be influenced by sex. (C) 2015 The Authors. Published by Elsevier Ltd. on behalf of IBRO.
引用
收藏
页码：424 / 435
页数：12
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