BUTYRYLCHOLINESTERASE-KNOCKOUT REDUCES BRAIN DEPOSITION OF FIBRILLAR β-AMYLOID IN AN ALZHEIMER MOUSE MODEL

被引：117

作者：

Reid, G. Andrew ^{[1
]}

Darvesh, Sultan ^{[1
,2
]}

机构：

[1] Dalhousie Univ, Dept Med Neurosci, Halifax, NS, Canada

[2] Dalhousie Univ, Dept Med Neurol & Geriatr Med, Halifax, NS, Canada

来源：

NEUROSCIENCE | 2015年 / 298卷

基金：

加拿大健康研究院;

关键词：

Alzheimer's disease; beta-amyloid; butyrylcholinesterase; 5XFAD mouse; butyrylcholinesterase-knock-out; cholinergic system; K-VARIANT; SEX-DIFFERENCES; APOLIPOPROTEIN E4; NO ASSOCIATION; 3XTG-AD MICE; DISEASE; ESTROGEN; CHOLINESTERASES; DEMENTIA; GENES;

D O I：

10.1016/j.neuroscience.2015.04.039

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In Alzheimer's disease (AD), numerous beta-amyloid (A beta) plaques are associated with butyrylcholinesterase (BChE) activity, the significance of which is unclear. A mouse model, containing five human familial AD genes (5XFAD), also develops A beta plaques with BChE activity. Knock-out of BChE in this model showed diminished fibrillar A beta plaque deposition, more so in males than females. This suggests that lack of BChE reduces deposition of fibrillar A beta in AD and this effect may be influenced by sex. (C) 2015 The Authors. Published by Elsevier Ltd. on behalf of IBRO.

引用

页码：424 / 435

页数：12

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