Cerebellar volume change in response to electroconvulsive therapy in patients with major depression

被引：40

作者：

Depping, Malte S. ^{[1
]}

Nolte, Henrike M. ^{[1
]}

Hirjak, Dusan ^{[1
,7
]}

Palm, Elisa ^{[1
]}

Hofer, Stefan ^{[2
]}

Stieltjes, Bram ^{[3
]}

Maier-Hein, Klaus ^{[4
]}

Sambataro, Fabio ^{[5
]}

Wolf, Robert C. ^{[1
,6
]}

Thomann, Philipp A. ^{[1
]}

机构：

[1] Heidelberg Univ, Ctr Psychosocial Med, Dept Gen Psychiat, Vosstr 2, D-69115 Heidelberg, Germany

[2] Heidelberg Univ, Dept Anaesthesiol, Heidelberg, Germany

[3] Univ Basel Hosp, Dept Radiol, Basel, Switzerland

[4] German Canc Res Ctr, Div Med & Biol Informat, Med Image Comp Grp, Heidelberg, Germany

[5] Univ Udine, Dept Expt & Clin Med Sci DISM, I-33100 Udine, Italy

[6] Univ Saarland, Dept Psychiat Psychotherapy & Psychosomat, Homburg, Germany

[7] Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Dept Psychiat & Psychotherapy, Mannheim, Germany

来源：

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | 2017年 / 73卷

关键词：

Electro-convulsive therapy; ECT; Depression; Cerebellum; Cerebellar volume; GRAY-MATTER VOLUME; AMYGDALA VOLUME; CONNECTIVITY; NEUROPLASTICITY; HIPPOCAMPAL; COGNITION; INSIGHTS; FMRI; ECT;

D O I：

10.1016/j.pnpbp.2016.09.007

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Electroconvulsive therapy (ECT) is remarkably effective in severe major depressive disorder (MDD). Growing evidence has accumulated for brain structural and functional changes in response to ECT, primarily within corticolimbic regions that have been considered in current neurobiological models of MDD. Despite increasing evidence for important cerebellar contributions to affective, cognitive and attentional processes, investigations on cerebellar effects of ECT in depression are yet lacking. In this study, using cerebellum-optimized voxel-based analysis methods, we investigated cerebellar volume in 12 MDD patients who received right-sided unilateral ECT. 16 healthy controls (HC) were included. Structural MRI data was acquired before and after ECT and controls were scanned once. Baseline structural differences in MDD compared to HC were located within the "cognitive cerebellum" and remained unchanged with intervention. ECT led to gray matter volume increase of left cerebellar area crus I, a region ascribed to the "affective/limbic cerebellum". The effects of ECT on cerebellar structure correlated with overall symptom relief. These findings provide preliminary evidence that structural change of the cerebellum in response to ECT may be related to the treatment's antidepressant effects. (C) 2016 Elsevier Inc All rights reserved.

引用

页码：31 / 35

页数：5

共 44 条

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