GENETICS OF T2DM IN 2016 Biological and translational insights from T2DM genetics

被引：11

作者：

McCarthy, Mark I. ^{[1
,2
]}

机构：

[1] Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Churchill Hosp, Old Rd, Oxford OX3 7LJ, England

[2] Univ Oxford, Wellcome Trust Ctr Human Genet, Roosevelt Dr, Oxford OX3 7BN, England

来源：

NATURE REVIEWS ENDOCRINOLOGY | 2017年 / 13卷 / 02期

关键词：

TYPE-2; PATHOPHYSIOLOGY; ARCHITECTURE; ASSOCIATION; VARIANT;

D O I：

10.1038/nrendo.2016.212

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Type 2 diabetes mellitus (T2DM) is a major global health challenge. Development of more effective strategies for prevention and therapy depends on an improved understanding of its pathogenetic mechanisms. 2016 ends a period during which large-scale discovery of risk alleles for T2DM became routine and heralds a shift in research focus towards their exploitation to fuel mechanistic insights.

引用

页码：71 / 72

页数：2

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