The inhibition of xanthine oxidase by the Schiff base zinc(II) complex

被引：54
作者：
You, Zhong-Lu
Shi, Da-Hua
Zhu, Hai-Liang
机构：
[1] Liaoning Normal Univ, Dept Chem & Chem Engn, Dalian 116029, Liaoning, Peoples R China
[2] Nanjing Univ, Inst Funct Biomol, State Key Lab Pharmaceut Biotechnol, Nanjing 210093, Peoples R China
来源：
INORGANIC CHEMISTRY COMMUNICATIONS | 2006年 / 9卷 / 06期
关键词：
Schiff base; zinc complex; xanthine oxidase; inhibition;
D O I：
10.1016/j.inoche.2006.03.023
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
A dinuclear Schiff base zinc(II) complex was synthesized, characterized and evaluated for the first time for its effect on the xanthine oxidase (XO). The complex showed higher XO inhibitory activity than those of the corresponding Schiff base ligand and the metal ion used in the preparation of the complex, and even more effective than the standard inhibitor allopurinol. (C) 2006 Elsevier B.V. All rights reserved.
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页码：642 / 644
页数：3
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