T helper 1-and T helper 2-type cytokine imbalance in pregnant women with pre-eclampsia

被引:113
作者
Darmochwal-Kolarz, D
Leszczynska-Gorzelak, B
Rolinski, J
Oleszczuk, J
机构
[1] Univ Lublin, Sch Med, Dept Clin Immunol, PL-20950 Lublin, Poland
[2] Univ Lublin, Sch Med, Dept Obstet & Perinatol, PL-20950 Lublin, Poland
来源
EUROPEAN JOURNAL OF OBSTETRICS GYNECOLOGY AND REPRODUCTIVE BIOLOGY | 1999年 / 86卷 / 02期
关键词
pre-eclampsia; pregnancy; Th1/Th2; imbalance; interleukin-2; interferon-gamma; interleukin-10;
D O I
10.1016/S0301-2115(99)00065-2
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Objectives: The purpose of our study was to investigate T helper 1/T helper 2 balance in pregnant women with pre-eclampsia. Study design: 18 patients with pre-eclampsia and 20 healthy pregnant women were included in the study. Peripheral blood mononuclear cells (PBMC) were stimulated with phytohaemagglutinin (PHA) for 48 h. Cytokine: interleukin-2 (Il-2), interferon-gamma (IFN-gamma) and interleukin-10 (Il-10) concentrations in culture supernatants were determined using the ELISA method. Statistical analysis was performed using a standard non-parametric Mann-Whitney U-test. Results: We found that in pre-eclamptic patients PHA-stimulated Il-2 and IFN-gamma production was significantly higher (P<0.001) and Il-10 production significantly lower (P<0.005) in comparison with the control group. Conclusion: These results could suggest that there is Th1/Th2 imbalance in pre-eclamptic patients with predominant Th1-type immunity. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码:165 / 170
页数:6
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