Leukemia/lymphoma-associated gene fusions in normal individuals

被引：14

作者：

Brassesco, M. S. ^{[1
]}

机构：

[1] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Pediat & Puericultura, Ribeirao Preto, SP, Brazil

来源：

GENETICS AND MOLECULAR RESEARCH | 2008年 / 7卷 / 03期

关键词：

Gene fusions; Genomic instability; Leukemia; Lymphoma; Healthy individuals;

D O I：

10.4238/vol7-3gmr486

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Hematopoietic neoplasias are characterized by recurrent chromosomal aberrations that result in the formation of gene fusions and the subsequent expression of chimeric proteins with unique properties. However, in recent years, different lymphoma/leukemia-associated rearrangements, such as BCR/ABL, IGH/BCL2, ETV6/RUNX1 and MLL duplications, have been detected in healthy individuals. The presence of these rearrangements indicates that such translocations can be generated in normal hematopoietic cells without apparent oncogenic consequences. This article reviews and discusses the data available in the literature.

引用

页码：782 / 790

页数：9

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[51]

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[52] Detection of t(14;18) carrying cells in bone marrow and peripheral blood from patients affected by non-lymphoid diseases [J].