Non-typhoidal Salmonella encephalopathy involving lipopolysaccharide in cattle

被引：4
|
作者：
Xiong, N. [1 ]
Brewer, M. T. [1 ]
Anderson, K. L. [1 ]
Carlson, S. A. [1 ]
机构：
[1] Iowa State Univ, Dept Biomed Sci, Coll Vet Med, Ames, IA 50011 USA
来源：
VETERINARY MICROBIOLOGY | 2013年 / 162卷 / 01期
关键词：
Salmonella; Neuropathogenicity; Lipopolysaccharide; POLYMYXIN-B; ESCHERICHIA-COLI; PATHOGENICITY; INACTIVATION; EXPRESSION; PRODUCTS; BACTERIA; RECEPTOR; MODEL; PCR;
D O I：
10.1016/j.vetmic.2012.08.007
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
This study assessed the involvement of lipopolysaccharide (LPS) in the non-typhoidal Salmonella encephalopathy (NTSE) caused by a unique isolate of Salmonella enterica serovar Saint-paul (SstpNPG). NTSE was prevented by genetic (deletion of murE) or pharmacologic (polymyxin) disruption of LPS on SstpNPG although the disruption of LPS did not deter brain penetration of the strain. This is the first study to demonstrate that LPS is involved in the manifestations of NTSE. (C) 2012 Elsevier B.V. All rights reserved.
引用
收藏
页码：285 / 287
页数：3
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