Subcortical gray matter structural alterations in prediabetes and type 2 diabetes

被引：17
作者：
Cui, Dong [1 ,2 ,6 ,7 ]
Liu, Xinfeng [4 ]
Liu, Minmin [5 ]
Cao, Weifang [1 ,2 ]
Xue, Yazhuo [3 ]
Guo, Yongxin [1 ,2 ]
Guo, Yancheng [3 ]
Lu, Aixia [3 ]
Jiao, Qing [1 ,2 ]
机构：
[1] Taishan Med Univ, Coll Radiol, 619 Changcheng Rd, Tai An 271016, Shandong, Peoples R China
[2] Taishan Med Univ, Collaborat Innovat Ctr Magnet Resonance Imaging B, Tai An, Shandong, Peoples R China
[3] Taishan Med Univ, Sch Nursing, Tai An, Shandong, Peoples R China
[4] Taishan Hosp Shandong Prov, Dept Endocrinol, Tai An, Shandong, Peoples R China
[5] Chinese Med Hosp, Dept Ophthalmol, Tai An, Shandong, Peoples R China
[6] Chinese Acad Med Sci, Inst Biomed Engn, Tianjin, Peoples R China
[7] Peking Union Med Coll, Tianjin, Peoples R China
来源：
NEUROREPORT | 2019年 / 30卷 / 06期
关键词：
gray matter volume; prediabetes; subcortical structural; type; 2; diabetes; HIPPOCAMPAL ATROPHY; ALZHEIMERS-DISEASE; VOLUME; MEMORY; COMPLICATIONS; DYSFUNCTION; GLUCOSE;
D O I：
10.1097/WNR.0000000000001224
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Type 2 diabetes (T2D) is a risk factor for cognitive impairment and potentially Alzheimer's disease. However, the precise mechanism underlying the effects of glucose on brain abnormalities is not fully understood. The differential effects of glucose alteration on brain changes in patients with T2D and those with prediabetes are also unclear. MRI data were collected from 21 patients with T2D (male/female, 7/14); 21 patients with prediabetes (male/female, 8/13); and 21 age-matched, sex-matched, and education-matched normal controls (male/female, 7/14). MRI data were analyzed using the Freesurfer software to obtain subcortical gray matter (GM) structural volumes. Spearman correlation analysis was performed between GM structural volume and clinical data. Reduced subcortical GM volumes were found in patients with prediabetes and those with T2D in the bilateral lateral hippocampus, left amygdala, and right putamen compared with healthy controls. In addition, postprandial blood sugar remained significantly associated with GM volume in the left hippocampus of patients with T2D. Our results indicate that prediabetes is not the harmless condition that it was previously thought to be, that impaired glycemia negatively affects the structures of the brain, and that long-lasting hyperglycemia accelerates brain atrophy in patients with T2D.
引用
收藏
页码：441 / 445
页数：5
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