Pediatric antiphospholipid syndrome

被引：34

作者：

Madison, Jacqueline A. ^{[1
]}

Zuo, Yu ^{[2
]}

Knight, Jason S. ^{[2
]}

机构：

[1] Univ Michigan, Dept Pediat, Div Pediat Rheumatol, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Dept Internal Med, Div Rheumatol, Ann Arbor, MI 48109 USA

来源：

EUROPEAN JOURNAL OF RHEUMATOLOGY | 2020年 / 7卷

关键词：

Antiphospholipid syndrome; antiphospholipid antibodies; catastrophic antiphospholipid syndrome; pediatric; neonatal; lupus; SYSTEMIC-LUPUS-ERYTHEMATOSUS; NEUTROPHIL EXTRACELLULAR TRAPS; EVIDENCE-BASED RECOMMENDATIONS; SYNDROME DESCRIPTIVE ANALYSIS; 14TH INTERNATIONAL-CONGRESS; PROTEIN-S DEFICIENCY; TASK-FORCE REPORT; ANTI-BETA(2)-GLYCOPROTEIN-I ANTIBODIES; NEUROPSYCHIATRIC MANIFESTATIONS; ANTICARDIOLIPIN ANTIBODIES;

D O I：

10.5152/eurjrheum.2019.19160

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Despite its potential to cause significant morbidity in children, pediatric antiphospholipid syndrome (APS) is an understudied condition. In this review, we will cover what is known about pediatric APS epidemiology and how the clinician might approach the diagnosis of pediatric APS. We will highlight similarities and differences with the adult disease, both for primary APS and in the context of lupus. Clinical manifestations beyond thrombosis, especially neurologic and hematologic in nature, will be discussed. We will also consider what unique implications antiphospholipid antibody-positivity may have for children with lupus and for neonates born to mothers with APS. The approach to treatment will be covered, including the unique impact of APS medications on children as compared with adults. Finally, the importance of future mechanistic research is emphasized as physicians endeavor to provide the personalized care that children with APS clearly deserve.

引用

页码：S3 / S12

页数：10

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