The role of cytokines in the pathogenesis and treatment of HIV infection

被引：72
作者：
Catalfamo, Marta [1 ]
Le Saout, Cecile [1 ]
Lane, H. Clifford [1 ]
机构：
[1] NIAID, Immunoregulat Lab, NIH, Bethesda, MD 20892 USA
来源：
CYTOKINE & GROWTH FACTOR REVIEWS | 2012年 / 23卷 / 4-5期
关键词：
CD4 and CD8 T cell immune activation; T cell homeostasis; IL-7; Type-I IFN; HUMAN-IMMUNODEFICIENCY-VIRUS; CD4(+) T-CELLS; ACTIVE ANTIRETROVIRAL THERAPY; TYPE-1; INFECTION; SIV INFECTION; GASTROINTESTINAL-TRACT; IMMUNE ACTIVATION; I INTERFERON; VIRAL LOAD; B-CELLS;
D O I：
10.1016/j.cytogfr.2012.05.007
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
HIV immune activation plays an important role in the immunopathogenesis of the disease. The mechanisms driving this immune activation are partially defined and likely are the result of multiple factors. The introduction of combination antiretroviral therapy (cART) has improved the life expectancy of HIV infected individuals, however there is evidence that in the setting of "undetectable" HIV-RNA plasma levels, there is some level of persistent immune activation in these patients. A better understanding of the immune activation pathways should be of value in developing complementary therapies to restore the immune systems of patients with HIV infection. This review discusses the cytokine mediated pathways of immune activation of the CD4 and CD8 T cell pools during HIV infection. Published by Elsevier Ltd.
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收藏
页码：207 / 214
页数：8
相关论文
共 106 条
  • [1] Abrams D, 2009, NEW ENGL J MED, V361, P1548, DOI 10.1056/NEJMoa0903175
  • [2] ASCHER MS, 1988, CLIN EXP IMMUNOL, V73, P165
  • [3] Lymphocyte kinetics in health and disease
    Asquith, Becca
    Borghans, Jose A. M.
    Ganusov, Vitaly V.
    Macallan, Derek C.
    [J]. TRENDS IN IMMUNOLOGY, 2009, 30 (04) : 182 - 189
  • [4] Baker JV, 2010, J ACQ IMMUN DEF SYND, V56, P36
  • [5] Human interferons alpha, beta and omega
    Bekisz, J
    Schmeisser, H
    Hernandez, J
    Goldman, ND
    Zoon, KC
    [J]. GROWTH FACTORS, 2004, 22 (04) : 243 - 251
  • [6] HIV inhibits CD4+ T-cell proliferation by inducing indoleamine 2,3-dioxygenase in plasmacytoid dendritic cells
    Boasso, Adriano
    Herbeuval, Jean-Philippe
    Hardy, Andrew W.
    Anderson, Stephanie A.
    Dolan, Matthew J.
    Fuchs, Dietmar
    Shearer, Gene M.
    [J]. BLOOD, 2007, 109 (08) : 3351 - 3359
  • [7] How does indoleamine 2,3-dioxygenase contribute to HIV-mediated immune dysregulation
    Boasso, Adriano
    Shearer, Gene M.
    [J]. CURRENT DRUG METABOLISM, 2007, 8 (03) : 217 - 223
  • [8] HIV-Induced Type I Interferon and Tryptophan Catabolism Drive T Cell Dysfunction Despite Phenotypic Activation
    Boasso, Adriano
    Hardy, Andrew W.
    Anderson, Stephanie A.
    Dolan, Matthew J.
    Shearer, Gene M.
    [J]. PLOS ONE, 2008, 3 (08):
  • [9] Global genomic analysis reveals rapid control of a robust innate response in SIV-infected sooty mangabeys
    Bosinger, Steven E.
    Li, Qingsheng
    Gordon, Shari N.
    Klatt, Nichole R.
    Duan, Lijie
    Xu, Luoling
    Francella, Nicholas
    Sidahmed, Abubaker
    Smith, Anthony J.
    Cramer, Elizabeth M.
    Zeng, Ming
    Masopust, David
    Carlis, John V.
    Ran, Longsi
    Vanderford, Thomas H.
    Paiardini, Mirko
    Isett, R. Benjamin
    Baldwin, Don A.
    Else, James G.
    Staprans, Silvija I.
    Silvestri, Guido
    Haase, Ashley T.
    Kelvin, David J.
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2009, 119 (12) : 3556 - 3572
  • [10] HIV disease: fallout from a mucosal catastrophe?
    Brenchley, JM
    Price, DA
    Douek, DC
    [J]. NATURE IMMUNOLOGY, 2006, 7 (03) : 235 - 239
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