Serum Alpha-Fetoprotein Predicts Treatment Outcome in Chronic Hepatitis C Patients Regardless of HCV Genotype

被引：15

作者：

Abdoul, Hendy ^{[1
]}

Mallet, Vincent ^{[2
]}

Pol, Stanislas ^{[2
]}

Fontanet, Arnaud ^{[1
]}

机构：

[1] Inst Pasteur, Unite Epidemiol Malad Emergentes, Paris, France

[2] Univ Paris 05, Hop Cochin, APHP, Unite Hepatol, INSERM U567, Paris, France

来源：

PLOS ONE | 2008年 / 3卷 / 06期

关键词：

D O I：

10.1371/journal.pone.0002391

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We examined the association between serum alpha-fetoprotein (AFP) level and sustained virological response (SVR) in 93 chronic hepatitis C patients. The SVR rate was much higher among patients with serum AFP levels below rather than above the median value (5.7 ng/ml) (58.7% and 19.2%, respectively; P < 0.0001). Serum AFP should be added to the list of factors predictive of treatment response in chronic hepatitis C.

引用

页数：4

共 12 条

[1] An algorithm for the grading of activity in chronic hepatitis C
Bedossa, P
Poynard, T
[J]. HEPATOLOGY, 1996, 24 (02) : 289 - 293
[2] Prediction of treatment outcome in patients with chronic hepatitis C: Significance of baseline parameters and viral dynamics during therapy
Berg, T
Sarrazin, C
Herrmann, E
Hinrichsen, H
Gerlach, T
Zachoval, R
Wiedenmann, B
Hopf, U
Zeuzem, S
[J]. HEPATOLOGY, 2003, 37 (03) : 600 - 609
[3] DABEVA MD, 1993, AM J PATHOL, V143, P1606
[4] GERMAIN L, 1988, CANCER RES, V48, P368
[5] Test characteristics of α-fetoprotein for detecting hepatocellular carcinoma in patients with hepatitis C -: A systematic review and critical analysis
Gupta, S
Bent, S
Kohlwes, J
[J]. ANNALS OF INTERNAL MEDICINE, 2003, 139 (01) : 46 - 50
[6] IDENTIFICATION OF A NEW NORMAL EMBRYONIC HAEMOGLOBIN
HALBRECHT, I
KLIBANSKI, C
[J]. NATURE, 1956, 178 (4537) : 794 - 795
[7] Males S, 2007, ANTIVIR THER, V12, P797
[8] Is an "a la carte" combination interferon alfa-2b plus ribavirin regimen possible for the first line treatment in patients with chronic hepatitis C?
Poynard, T
McHutchison, J
Goodman, Z
Ling, MH
Albrecht, J
[J]. HEPATOLOGY, 2000, 31 (01) : 211 - 218
[9] SHIOJIRI N, 1991, CANCER RES, V51, P2611
[10] ALPHA-FETOPROTEIN - REEVALUATION IN HEPATOLOGY
TAKETA, K
[J]. HEPATOLOGY, 1990, 12 (06) : 1420 - 1432

← 1 2 →