Neoadjuvant Radiotherapy-Related Wound Morbidity in Soft Tissue Sarcoma: Perspectives for Radioprotective Agents

被引：16
作者：
Callaghan, Cameron M. [1 ,2 ,3 ]
Hasibuzzaman, M. M. [1 ,4 ]
Rodman, Samuel N. [1 ,5 ]
Goetz, Jessica E. [5 ]
Mapuskar, Kranti A. [1 ]
Petronek, Michael S. [1 ]
Steinbach, Emily J. [1 ]
Miller, Benjamin J. [5 ]
Pulliam, Casey F. [4 ]
Coleman, Mitchell C. [5 ]
Monga, Varun V. [2 ,3 ]
Milhem, Mohammed M. [2 ,3 ]
Spitz, Douglas R. [1 ]
Allen, Bryan G. [1 ,2 ,3 ]
机构：
[1] Univ Iowa Hosp & Clin, Dept Radiat Oncol, Free Rad & Radiat Biol Program, Iowa City, IA 52422 USA
[2] Univ Iowa Hosp & Clin, Holden Comprehens Canc Ctr, Iowa City, IA 52422 USA
[3] Univ Iowa Hosp & Clin, Dept Surg, Iowa City, IA 52422 USA
[4] Univ Iowa, Interdisciplinary Grad Program Human Toxicol, Iowa City, IA 52422 USA
[5] Univ Iowa Hosp & Clin, Dept Orthoped & Rehabil, Iowa City, IA 52422 USA
来源：
CANCERS | 2020年 / 12卷 / 08期
关键词：
wound healing; soft tissue sarcoma; radiotherapy complications; radioprotective agents; neoadjuvant radiotherapy; limb preservation; HIGH-DOSE-RATE; MODULATED RADIATION-THERAPY; EXTERNAL-BEAM RADIATION; LIMB-SPARING SURGERY; HIGH-RISK EXTREMITY; POSTOPERATIVE RADIOTHERAPY; PREOPERATIVE RADIATION; RANDOMIZED-TRIAL; RATE BRACHYTHERAPY; LOCAL-CONTROL;
D O I：
10.3390/cancers12082258
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Historically, patients with localized soft tissue sarcomas (STS) of the extremities would undergo limb amputation. It was subsequently determined that the addition of radiation therapy (RT) delivered prior to (neoadjuvant) or after (adjuvant) a limb-sparing surgical resection yielded equivalent survival outcomes to amputation in appropriate patients. Generally, neoadjuvant radiation offers decreased volume and dose of high-intensity radiation to normal tissue and increased chance of achieving negative surgical margins-but also increases wound healing complications when compared to adjuvant radiotherapy. This review elaborates on the current neoadjuvant/adjuvant RT approaches, wound healing complications in STS, and the potential application of novel radioprotective agents to minimize radiation-induced normal tissue toxicity.
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页码：1 / 26
页数：26
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