Photoredox-Mediated C-H Functionalization and Coupling of Tertiary Aliphatic Amines with 2-Chloroazoles

被引：58

作者：

Singh, Anuradha ^{[1
]}

Arora, Amandeep ^{[1
]}

Weaver, Jimmie D. ^{[1
]}

机构：

[1] Oklahoma State Univ, Dept Chem, Stillwater, OK 74078 USA

来源：

ORGANIC LETTERS | 2013年 / 15卷 / 20期

关键词：

BIOMIMETIC SYNTHESIS; RADICAL-ADDITION; OXIDATION; EFFICIENT; STRATEGY; BONDS;

D O I：

10.1021/ol402751j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Herein, conditions for C-H functionalization of tertiary aliphatic amines and their subsequent coupling with a number of 2-chloroazole derivatives are reported. The reaction is facilitated by a catalytic amount of tris-fac-Ir(ppy)3, with blue light irradiation and takes place under mild and convenient conditions. Most couplings take place with excellent regioselectivity. The reaction is tolerant of a number of functional groups and allows for rapid access to alpha-azole carbinamines commonly found in post-translationally modified peptides.

引用

页码：5390 / 5393

页数：4

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