The effects of electric field and size on the electron-phonon interaction with an on-center impurity in a Zn1-xCdxSe/ZnSe spherical quantum dot are studied, taking into account the interactions with confined, half-space and surface optical phonons. In addition, the interaction between impurity and phonons has also been considered. The results show that the electron-confined, electron-half-space, and electron-surface optical phonon interaction energies are all negative. The electron-confined optical phonon interaction energy is weakened by the electric field, but the electron-half-space and electron-surface optical phonon interaction energies are strengthened by it. In particular, the electron-surface optical phonon interaction depends strongly on the electric field, and it will vanish when the electric field is absent. It is also found that the electron-confined optical phonon interaction and electron-impurity "exchange" interaction energies reach a peak values as the quantum dot radius increases and then gradually decrease, but the electron-half-space optical phonon interaction energy exponentially quickly approaches 0 as the quantum dot radius increases.