Thyroid hormone action at the cellular, genomic and target gene levels

被引：168
作者：
Yen, PM
Ando, S
Feng, X
Liu, Y
Maruvada, P
Xia, XM
机构：
[1] Johns Hopkins Bayview Med Ctr, Dept Med, Baltimore, MD 21224 USA
[2] Natl Inst Diabet Digest & Kidney Dis, Clin Endocrinol Branch, NIH, Bethesda, MD USA
来源：
MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2006年 / 246卷 / 1-2期
关键词：
thyroid hormone receptor; transcription; green fluorescent protein; microarray; chromatin immunprecipitation assay;
D O I：
10.1016/j.mce.2005.11.030
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Thyroid hormone (TH) plays important roles in metabolism, growth and differentiation. Thyroid hormone receptors (TRs) are ligand-regulatable transcription factors that bind both TH and DNA enhancer sequences in the promoter region of target genes where they can interact with co-repressor and co-activator complexes. These interactons, in turn, have consequent effects on transcription. This review describes studies on TH action from our laboratory examining the cellular localization and motility of TRs using green fluorescent fusion proteins. gene expression profiles of TH in WT and TR alpha and TR beta KO mice, as well as general transcription factor and co-activator recruitment on the promoters of target genes by TH in chromatin immunoprecipitation assays. (c) 2006 Published by Elsevier Ireland Ltd.
引用
收藏
页码：121 / 127
页数：7
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