Development of a practical high-yield industrial synthesis of pergolide mesylate

被引：11

作者：

Cabri, W ^{[1
]}

Roletto, J ^{[1
]}

Olmo, S ^{[1
]}

Fonte, P ^{[1
]}

Ghetti, P ^{[1
]}

Songia, S ^{[1
]}

Mapelli, E ^{[1
]}

Alpegiani, M ^{[1
]}

Paissoni, P ^{[1
]}

机构：

[1] Antibioticos SpA, Res & Dev, I-20090 Rodano, MI, Italy

来源：

ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2006年 / 10卷 / 02期

关键词：

D O I：

10.1021/op0501747

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The development of a high-yield and low environmental impact synthesis able to deliver highly pure pergolide mesylate 1 is described. The process [seven chemical steps (four telescoped), three steps of isolation of intermediate, and only one drying] affords pergolide mesylate 1 in 75-81% overall yield from dihydrolysergic acid 4 with > 99.8% purity.

引用

收藏

页码：198 / 202

页数：5

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