Regulation of the timing of oligodendrocyte differentiation: mechanisms and perspectives

被引：45
作者：
Huang, Hao [1 ]
Zhao, Xiao-Feng [1 ]
Zheng, Kang [1 ]
Qiu, Mengsheng [1 ,2 ]
机构：
[1] Hangzhou Normal Univ, Coll Life Sci, Inst Dev & Regenerat Biol, Hangzhou 310018, Zhejiang, Peoples R China
[2] Univ Louisville, Dept Anat Sci & Neurobiol, Louisville, KY 40292 USA
来源：
NEUROSCIENCE BULLETIN | 2013年 / 29卷 / 02期
基金：
中国国家自然科学基金;
关键词：
oligodendrocytes; differentiation; timing; remyelination; CELL-INTRINSIC TIMER; SPINAL-CORD; PRECURSOR CELLS; TRANSCRIPTION FACTORS; GENE-EXPRESSION; RECEPTOR GPR17; GROWTH-FACTOR; PROTEIN; MYELINATION; OLIG2;
D O I：
10.1007/s12264-013-1314-2
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Axonal myelination is an essential process for normal functioning of the vertebrate central nervous system. Proper formation of myelin sheaths around axons depends on the timely differentiation of oligodendrocytes. This differentiation occurs on a predictable schedule both in culture and during development. However, the timing mechanisms for oligodendrocyte differentiation during normal development have not been fully uncovered. Recent studies have identified a large number of regulatory factors, including cell-intrinsic factors and extracellular signals, that could control the timing of oligodendrocyte differentiation. Here we provide a mechanistic and critical review of the timing control of oligodendrocyte differentiation.
引用
收藏
页码：155 / 164
页数：10
相关论文
共 78 条
[11]   NG2-positive oligodendrocyte progenitor cells in adult human brain and multiple sclerosis lesions [J].
Chang, A ;
Nishiyama, A ;
Peterson, J ;
Prineas, J ;
Trapp, BD .
JOURNAL OF NEUROSCIENCE, 2000, 20 (17) :6404-6412
[12]   The oligodendrocyte-specific G protein-coupled receptor GPR17 is a cell-intrinsic timer of myelination [J].
Chen, Ying ;
Wu, Heng ;
Wang, Shuzong ;
Koito, Hisami ;
Li, Jianrong ;
Ye, Feng ;
Hoang, Jenny ;
Escobar, Sabine S. ;
Gow, Alexander ;
Arnett, Heather A. ;
Trapp, Bruce D. ;
Karandikar, Nitin J. ;
Hsieh, Jenny ;
Lu, Q. Richard .
NATURE NEUROSCIENCE, 2009, 12 (11) :1398-1406
[13]   Bone morphogenetic protein signaling and olig1/2 interact to regulate the differentiation and maturation of adult oligodendrocyte precursor cells [J].
Cheng, Xiaoxin ;
Wang, Yaping ;
He, Qian ;
Qiu, Mengsheng ;
Whittemore, Scott R. ;
Cao, Qilin .
STEM CELLS, 2007, 25 (12) :3204-3214
[14]   A crucial role for p57Kip2 in the intracellular timer that controls oligodendrocyte differentiation [J].
Dugas, Jason C. ;
Ibrahim, Adiljan ;
Barres, Ben A. .
JOURNAL OF NEUROSCIENCE, 2007, 27 (23) :6185-6196
[15]   Dicer1 and miR-219 Are Required for Normal Oligodendrocyte Differentiation and Myelination [J].
Dugas, Jason C. ;
Cuellar, Trinna L. ;
Scholze, Anja ;
Ason, Brandon ;
Ibrahim, Adiljan ;
Emery, Ben ;
Zamanian, Jennifer L. ;
Foo, Lynette C. ;
McManus, Michael T. ;
Barres, Ben A. .
NEURON, 2010, 65 (05) :597-611
[16]  
Durand B, 2000, BIOESSAYS, V22, P64
[17]   Accumulation of the cyclin-dependent kinase inhibitor p27/Kip1 and the timing of oligodendrocyte differentiation [J].
Durand, B ;
Gao, FB ;
Raff, M .
EMBO JOURNAL, 1997, 16 (02) :306-317
[18]   Myelin Gene Regulatory Factor Is a Critical Transcriptional Regulator Required for CNS Myelination [J].
Emery, Ben ;
Agalliu, Dritan ;
Cahoy, John D. ;
Watkins, Trent A. ;
Dugas, Jason C. ;
Mulinyawe, Sara B. ;
Ibrahim, Adilijan ;
Ligon, Keith L. ;
Rowitch, David H. ;
Barres, Ben A. .
CELL, 2009, 138 (01) :172-185
[19]   Dysregulation of the Wnt pathway inhibits timely myelination and remyelination in the mammalian CNS [J].
Fancy, Stephen P. J. ;
Baranzini, Sergio E. ;
Zhao, Chao ;
Yuk, Dong-In ;
Irvine, Karen-Amanda ;
Kaing, Sovann ;
Sanai, Nader ;
Franklin, Robin J. M. ;
Rowitch, David H. .
GENES & DEVELOPMENT, 2009, 23 (13) :1571-1585
[20]   Wnt signaling is sufficient to perturb oligodendrocyte maturation [J].
Feigenson, Keith ;
Reid, Mary ;
See, Jill ;
Crenshaw, E. Bryan, III ;
Grinspan, Judith B. .
MOLECULAR AND CELLULAR NEUROSCIENCE, 2009, 42 (03) :255-265
12345678