Dermal Dendritic Cells comprise two distinct populations:: CD1+ dendritic cells and CD209+ macrophages

被引：95

作者：

Ochoa, Maria Teresa ^{[1
]}

Loncaric, Anya ^{[1
]}

Krutzik, Stephan R. ^{[1
]}

Becker, Todd C. ^{[1
]}

Modlin, Robert L. ^{[1
,2
,3
]}

机构：

[1] Univ Calif Los Angeles, David Geffen Sch Med, Div Dermatol, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, David Geffen Sch Med, Dept Microbiol & Immunol, Los Angeles, CA 90095 USA

[3] Univ Calif Los Angeles, David Geffen Sch Med, Inst Mol Biol, Los Angeles, CA 90095 USA

来源：

JOURNAL OF INVESTIGATIVE DERMATOLOGY | 2008年 / 128卷 / 09期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/jid.2008.56

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

A key cell type of the resident skin immune system is the dendritic cell (DC), which in normal skin is located in two distinct microanatomical compartments: Langerhans cells (LCs), mainly in the epidermis, and dermal DCs (DDCs), in the dermis. Here, the lineage of DDCs was investigated using monoclonal antibodies and immunohistology. We provide evidence that "DDC" comprise at least two major phenotypic populations of dendritic-appearing cells, immature DC expressing CD1, CD11c and CD208; and macrophages expressing CD209, CD206, CD163, and CD68. These data suggest that dermal dendritic-appearing macrophages comprise a novel part of the innate immune response in the resident skin immune system.

引用

页码：2225 / 2231

页数：7

共 30 条

[1] CELLS CONTAINING FACTOR-VIII SUBUNIT A IN BENIGN AND SOFT-TISSUE TUMORS [J].

ADANY, R .

HISTOPATHOLOGY, 1987, 11 (12) :1341-1343

[2] CHARACTERIZATION OF CONNECTIVE-TISSUE CELLS CONTAINING FACTOR-XIII SUBUNIT-A [J].

ADANY, R ;

GLUKHOVA, MA ;

KABAKOV, AY ;

MUSZBEK, L .

JOURNAL OF CLINICAL PATHOLOGY, 1988, 41 (01) :49-56

[3]

ADANY R, 1985, EUR J CELL BIOL, V38, P171

[4] MINOCYCLINE HYPERPIGMENTATION - MODEL FOR INSITU PHAGOCYTIC-ACTIVITY OF FACTOR-XIIIA POSITIVE DERMAL DENDROCYTES [J].

ALTMAN, DA ;

FIVENSON, DP ;

LEE, MW .

JOURNAL OF CUTANEOUS PATHOLOGY, 1992, 19 (04) :340-345

[5] IDENTIFICATION OF FACTOR-XIIIA IN CUTANEOUS TISSUE [J].

CERIO, R ;

SPAULL, J ;

JONES, EW .

HISTOPATHOLOGY, 1988, 13 (03) :362-362

[6] CHARACTERIZATION OF FACTOR-XIIIA POSITIVE DERMAL DENDRITIC CELLS IN NORMAL AND INFLAMED SKIN [J].

CERIO, R ;

GRIFFITHS, CEM ;

COOPER, KD ;

NICKOLOFF, BJ ;

HEADINGTON, JT .

BRITISH JOURNAL OF DERMATOLOGY, 1989, 121 (04) :421-431

[7] Macrophages and dendritic cells constitute a major subpopulation of cells in the mouse dermis [J].

Dupasquier, M ;

Stoitzner, P ;

van Oudenaren, A ;

Romani, N ;

Leenen, PJM .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2004, 123 (05) :876-879

[8] DISTINCTION OF CLASS-II MHC(+) LANGERHANS CELL-LIKE INTERSTITIAL DENDRITIC ANTIGEN-PRESENTING CELLS IN MURINE DERMIS FROM DERMAL MACROPHAGES [J].

DURAISWAMY, N ;

TSE, Y ;

HAMMERBERG, C ;

KANG, S ;

COOPER, KD .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1994, 103 (05) :678-683

[9] Expression of C-type lectin receptors by subsets of dendritic cells in human skin [J].

Ebner, S ;

Ehammer, Z ;

Holzmann, S ;

Schwingshackl, P ;

Forstner, M ;

Stoitzner, P ;

Huemer, GM ;

Fritsch, P ;

Romani, N .

INTERNATIONAL IMMUNOLOGY, 2004, 16 (06) :877-887

[10] The dendritic cell-specific adhesion receptor DC-SIGN internalizes antigen for presentation to T cells [J].

Engering, A ;

Geijtenbeek, TBH ;

van Vliet, SJ ;

Wijers, M ;

van Liempt, E ;

Demaurex, N ;

Lanzavecchia, A ;

Fransen, J ;

Figdor, CG ;

Piguet, V ;

van Kooyk, Y .

JOURNAL OF IMMUNOLOGY, 2002, 168 (05) :2118-2126

← 1 2 3 →