Comparison of Splicing Factor 3b Inhibitors in Human Cells

被引:38
作者
Gao, Yang [1 ]
Vogt, Andreas [2 ]
Forsyth, Craig J. [3 ]
Koide, Kazunori [1 ]
机构
[1] Univ Pittsburgh, Dept Chem, Pittsburgh, PA 15260 USA
[2] Univ Pittsburgh, Dept Computat & Syst Biol, Drug Discovery Inst, Pittsburgh, PA 15260 USA
[3] Ohio State Univ, Dept Chem & Biochem, Columbus, OH 43210 USA
关键词
antitumor agents; biological activity; natural products; RNA; splicing; PRE-MESSENGER-RNA; ANTITUMOR SUBSTANCES; STREPTOMYCES SP; PHYSICOCHEMICAL PROPERTIES; BIOLOGICAL-ACTIVITIES; NUCLEAR RETENTION; GENE-EXPRESSION; SPLICEOSTATIN-A; GEX1; COMPOUNDS; FR901464;
D O I
10.1002/cbic.201200558
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
[No abstract available]
引用
收藏
页码:49 / 52
页数:4
相关论文
共 41 条
[1]   Total syntheses, fragmentation studies, and antitumor/antiproliferative activities of FR901464 and its low picomolar analogue [J].
Albert, Brian J. ;
Sivaramakrishnan, Ananthapadmanabhan ;
Naka, Tadaatsu ;
Czaicki, Nancy L. ;
Koide, Kazunori .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2007, 129 (09) :2648-2659
[2]   Meayamycin inhibits pre-messenger RNA splicing and exhibits picomolar activity against multidrug-resistant cells [J].
Albert, Brian J. ;
McPherson, Peter A. ;
O'Brien, Kristine ;
Czaicki, Nancy L. ;
DeStefino, Vincent ;
Osman, Sami ;
Li, Miaosheng ;
Day, Billy W. ;
Grabowski, Paula J. ;
Moore, Melissa J. ;
Vogt, Andreas ;
Koide, Kazunori .
MOLECULAR CANCER THERAPEUTICS, 2009, 8 (08) :2308-2318
[3]   p53 is activated in response to disruption of the pre-mRNA splicing machinery [J].
Allende-Vega, N. ;
Dayal, S. ;
Agarwala, U. ;
Sparks, A. ;
Bourdon, J-C ;
Saville, M. K. .
ONCOGENE, 2013, 32 (01) :1-14
[4]   The In Vivo Kinetics of RNA Polymerase II Elongation during Co-Transcriptional Splicing [J].
Brody, Yehuda ;
Neufeld, Noa ;
Bieberstein, Nicole ;
Causse, Sebastien Z. ;
Boehnlein, Eva-Maria ;
Neugebauer, Karla M. ;
Darzacq, Xavier ;
Shav-Tal, Yaron .
PLOS BIOLOGY, 2011, 9 (01)
[5]   Reduced fidelity of branch point recognition and alternative splicing induced by the anti-tumor drug spliceostatin A [J].
Corrionero, Anna ;
Minana, Belen ;
Valcarcel, Juan .
GENES & DEVELOPMENT, 2011, 25 (05) :445-459
[6]   Splicing enhances recruitment of methyltransferase HYPB/Setd2 and methylation of histone H3 Lys36 [J].
de Almeida, Sergio Fernandes ;
Grosso, Ana Rita ;
Koch, Frederic ;
Fenouil, Romain ;
Carvalho, Silvia ;
Andrade, Jorge ;
Levezinho, Helena ;
Gut, Marta ;
Eick, Dirk ;
Gut, Ivo ;
Andrau, Jean-Christophe ;
Ferrier, Pierre ;
Carmo-Fonseca, Maria .
NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2011, 18 (09) :977-U1501
[7]   Herboxidiene: Determination of absolute configuration by degradation and synthetic studies [J].
Edmunds, AJF ;
Trueb, W ;
Oppolzer, W ;
Cowley, P .
TETRAHEDRON, 1997, 53 (08) :2785-2802
[8]   Sudemycins, Novel Small Molecule Analogues of FR901464, Induce Alternative Gene Splicing [J].
Fan, Liying ;
Lagisetti, Chandraiah ;
Edwards, Carol C. ;
Webb, Thomas R. ;
Potter, Philip M. .
ACS CHEMICAL BIOLOGY, 2011, 6 (06) :582-589
[9]   The anti-tumor drug E7107 reveals an essential role for SF3b in remodeling U2 snRNP to expose the branch point-binding region [J].
Folco, Eric G. ;
Coil, Kaitlyn E. ;
Reed, Robin .
GENES & DEVELOPMENT, 2011, 25 (05) :440-444
[10]   Spliceostatin A blocks angiogenesis by inhibiting global gene expression including VEGF [J].
Furumai, Ryohei ;
Uchida, Kazuyo ;
Komi, Yusuke ;
Yoneyama, Misao ;
Ishigami, Ken ;
Watanabe, Hidenori ;
Kojima, Soichi ;
Yoshida, Minoru .
CANCER SCIENCE, 2010, 101 (11) :2483-2489