Antitumor Immunomodulatory Activity of Allogenic Bone Marrow Cells on TiNi Scaffold

被引：0
|
作者：
Kokorev, O. V. [1 ]
Hodorenko, V. N. [1 ]
Cherdyntseva, N. V. [2 ]
Gunther, V. E. [1 ]
机构：
[1] Tomsk State Univ, Tomsk 634050, Russia
[2] Tomsk Canc Res Inst, Tomsk 634050, Russia
来源：
PHYSICS OF CANCER: INTERDISCIPLINARY PROBLEMS AND CLINICAL APPLICATIONS (PC'16) | 2016年 / 1760卷
关键词：
NITI;
D O I：
10.1063/1.4960248
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The present study was undertaken to evaluate the feasibility of modulation of anti-tumor response by allogenic bone marrow cell transplantation into porous TiNi-based scaffold. Transplantation of bone marrow cells into porous TiNi-based scaffold leads to antitumor (35%) and antimetastatic (55%) effects. The lifetime of tumor-bearing animals and implanted allogenic bone marrow cells in incubator of TiNi increases up to 60%. The possible mechanisms of the effect of allogenic cells on tumor process are the stimulation of endogenous effectors of antitumor immunity.
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页数：5
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