Development of drug delivery systems based on nanostructured porous silicon loaded with the anti-tumoral drug emodin adsorbed on silver nanoparticles

被引：1
|
作者：
Hernandez, Margarita [1 ]
Recio, Gonzalo [2 ]
Sevilla, Paz [1 ,3 ]
Torres-Costa, Vicente [2 ]
Garcia-Ramos, Jose V. [1 ]
Domingo, Concepcion [1 ]
Martin-Palma, Raul J. [2 ]
机构：
[1] CSIC, Inst Estruct Mat, C Serrano 121, Madrid 28006, Spain
[2] Univ Autonoma Madrid, Dept Fis Aplicada, E-28049 Madrid, Spain
[3] Univ Complutense Madrid, Fac Farmac, Dept Quim Fis, Madrid 28040, Spain
来源：
NANOSTRUCTURED THIN FILMS V | 2012年 / 8465卷
关键词：
Nanostructured porous silicon; emodin; Raman; drug delivery;
D O I：
10.1117/12.931117
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
A study of the fluorescence and Raman spectra of a new and complex drug delivery system formed by emodin adsorbed on silver nanoparticles embedded into a matrix of porous silicon is here reported. Several experimental methods of inclusion of the drug-silver set inside the pores, without previous functionalization of porous silicon, have been tested in order to optimize the conditions for the fluorescence detection of emodin. In this sense, we have also added bovine serum albumin to the system, finding that the presence of the protein enhances the fluores-cence signal from emodin.
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页数：5
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