Research progress on exosomes derived from mesenchymal stem cells in hematological malignancies

被引：5

作者：

Lyu, Tianxin ^{[1
,2
]}

Zhang, Binglei ^{[2
]}

Li, Mengjia ^{[3
]}

Jiao, Xueli ^{[1
]}

Song, Yongping ^{[4
]}

机构：

[1] Zhengzhou Univ, Affiliated Canc Hosp, Dept Hematol, Zhengzhou, Peoples R China

[2] Zhengzhou Univ, Acad Med Sci, Zhengzhou, Peoples R China

[3] Zhengzhou Univ, Sch Life Sci, Zhengzhou, Peoples R China

[4] Zhengzhou Univ, Affiliated Hosp 1, Dept Hematol, Zhengzhou, Peoples R China

来源：

HEMATOLOGICAL ONCOLOGY | 2021年 / 39卷 / 02期

关键词：

exosome; hematological malignancy; mesenchymal stem cell; VERSUS-HOST-DISEASE; STROMAL CELLS; EXTRACELLULAR VESICLES; LEUKEMIA-CELLS; MOUSE MODEL; T-CELLS; THERAPY; PROLIFERATION; ACTIVATION; RESISTANCE;

D O I：

10.1002/hon.2793

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Mesenchymal stem cells (MSCs) are a subset of multifunctional stem cells with self-renewal and multidirectional differentiation properties that play a pivotal role in tumor progression. MSCs are reported to exert biological functions by secreting specialized vesicles, known as exosomes, with tumor cells. Exosomes participate in material and information exchange between cells and are crucial in multiple physiological and pathological processes. This study provides a comprehensive overview of the roles, mechanisms of action and sources of MSC exosomes in hematological malignancies, and different tumor types.

引用

页码：162 / 169

页数：8

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