A serum amyloid A-positive hepatocellular neoplasm arising in alcoholic cirrhosis: a previously unrecognized type of inflammatory hepatocellular tumor

被引:29
作者
Sasaki, Motoko [1 ]
Yoneda, Norihide [1 ,2 ]
Kitamura, Seiko [3 ]
Sato, Yasunori [1 ]
Nakanuma, Yasuni [1 ]
机构
[1] Kanazawa Univ Hosp, Dept Human Pathol, Kanazawa, Ishikawa, Japan
[2] Kanazawa Univ, Grad Sch Med, Dept Radiol, Kanazawa, Ishikawa 9208640, Japan
[3] Kanazawa Univ Hosp, Diagnost Pathol Sect, Kanazawa, Ishikawa, Japan
关键词
alcoholic cirrhosis; dysplatic nodule; hepatocellular carcinoma; inflammatory hepatocellular adenoma; serum amyloid A protein; FOCAL NODULAR HYPERPLASIA; PHENOTYPIC CLASSIFICATION; LIVER-CIRRHOSIS; ADENOMA; EXPRESSION; MARKERS;
D O I
10.1038/modpathol.2012.114
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Hepatocellular adenoma usually arises in the absence of significant fibrosis. Herein, we report seven patients with serum amyloid A-positive hepatocellular neoplasm, which shares features with inflammatory hepatocellular adenoma arising in alcoholic cirrhosis. Seven patients (two women and five men, age range 41-67 years) with hypervascular hepatocellular nodules associated with alcoholic cirrhosis were retrieved from our pathological files (1997-2011). The hepatocellular nodules were multiple (43) in all patients and 17 nodules were histologically examined. We surveyed the immunoreactivity for serum amyloid A, glutamine synthetase, and glypican-3 in the hepatocellular nodules and control lesions, including 5 focal nodular hyperplasia, 18 dysplastic nodules, and 54 hepatocellular carcinomas in various background diseases. In all, 15 of 17 nodules showed strong and distinct immunoreactivity for serum amyloid A, sharing features with inflammatory hepatocellular adenoma. The serum amyloid A-positive hepatocellular neoplasms showed increased cellular density, inflammatory infiltrate, sinusoidal dilatation, and ductular reaction to various degrees. Although about a half of dysplastic nodules and hepatocellular carcinomas showed focal immunoreactivity for serum amyloid A, the extent of serum amyloid A expression was significantly higher in serum amyloid A-positive hepatocellular neoplasms, than in control nodules. The serum amyloid A-positive hepatocellular neoplasms did not show the overexpression of glutamine synthetase or immunoreactivity for glypican-3. In contrast, most hepatocellular carcinomas showed the overexpression of glutamine synthetase and immunoreactivity for glypican-3, irrespective of background diseases. In conclusion, this study highlights a characteristic group of hepatocellular neoplasms arising in alcoholic cirrhosis, which share features with inflammatory hepatocellular adenomas. These serum amyloid A-positive hepatocellular neoplasms may be a new type of inflammatory hepatocellular tumors in alcoholic patients. Modern Pathology (2012) 25, 1584-1593; doi:10.1038/modpathol.2012.114; published online 6 July 2012
引用
收藏
页码:1584 / 1593
页数:10
相关论文
共 17 条
[1]  
[Anonymous], 2010, WHO CLASSIFICATION T
[2]   Hepatocellular adenoma subtype classification using molecular markers and lmmunohistochemistry [J].
Bioulac-Sage, Paulette ;
Rebouissou, Sandra ;
Thomas, Cristel ;
Blanc, Jean-Frederic ;
Saric, Jean ;
Cunha, Antonio Sa ;
Ruiller, Anne ;
Cubel, Gaeelle ;
Couchy, Gabrielle ;
Imbeaud, Sandrine ;
Balabaud, Charles ;
Zucman-Rossi, Jessica .
HEPATOLOGY, 2007, 46 (03) :740-748
[3]   Hepatocellular Adenoma Management and Phenotypic Classification: the Bordeaux Experience [J].
Bioulac-Sage, Paulette ;
Laumonier, Herve ;
Couchy, Gabrielle ;
Le Bail, Brigitte ;
Cunha, Antonio Sa ;
Rullier, Anne ;
Laurent, Christophe ;
Blanc, Jean-Frederic ;
Cubel, Gaelle ;
Trillaud, Herve ;
Zucman-Rossi, Jessica ;
Balabaud, Charles ;
Saric, Jean .
HEPATOLOGY, 2009, 50 (02) :481-489
[4]   Over-expression of glutamine synthetase in focal nodular hyperplasia: a novel easy diagnostic tool in surgical pathology [J].
Bioulac-Sage, Paulette ;
Laumonier, Hervr ;
Rullier, Anne ;
Cubel, Gaelle ;
Laurent, Christophe ;
Zucman-Rossi, Jessica ;
Balabaud, Charles .
LIVER INTERNATIONAL, 2009, 29 (03) :459-465
[5]   The application of markers (HSP70 GPC3 and GS) in liver biopsies is useful for detection of hepatocellular carcinoma [J].
Di Tommaso, Luca ;
Destro, Annarita ;
Seok, Jae Yeon ;
Balladore, Emanuela ;
Terracciano, Luigi ;
Sanglovanni, Angelo ;
Iavarone, Massimo ;
Colombo, Massimo ;
Jang, Ja June ;
Yu, Eunsil ;
Jin, So Young ;
Morenghi, Emanuela ;
Park, Young Nyun ;
Roncalli, Massimo .
JOURNAL OF HEPATOLOGY, 2009, 50 (04) :746-754
[6]   Changing trends in malignant transformation of hepatocellular adenoma [J].
Farges, Olivier ;
Ferreira, Nelio ;
Dokmak, Safi ;
Belghiti, Jacques ;
Bedossa, Pierre ;
Paradis, Valerie .
GUT, 2011, 60 (01) :85-89
[7]   ROLE OF INTERLEUKIN-6 IN REGULATING SYNTHESIS OF C-REACTIVE PROTEIN AND SERUM AMYLOID-A IN HUMAN HEPATOMA-CELL LINES [J].
GANAPATHI, MK ;
MAY, LT ;
SCHULTZ, D ;
BRABENEC, A ;
WEINSTEIN, J ;
SEHGAL, PB ;
KUSHNER, I .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1988, 157 (01) :271-277
[8]   Imaging of benign hypervascular hepatocellular nodules in alcoholic liver cirrhosis: Differentiation from hypervascular hepatocellular carcinoma [J].
Kobayashi, Satoshi ;
Matsui, Osamu ;
Kamura, Takeshi ;
Yamamoto, Satoshi ;
Yoneda, Norihide ;
Gabata, Toshifumi ;
Terayama, Noboru ;
Sanada, Junichiro .
JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY, 2007, 31 (04) :557-563
[9]  
Konishi M, 1995, ACTA HEPATOL JPN, V36, P223
[10]   Unique hypervascular nodules in alcoholic liver cirrhosis: identical to focal nodular hyperplasia-like nodules? [J].
Nakashima, O ;
Kurogi, M ;
Yamaguchi, R ;
Miyaaki, H ;
Fujimoto, M ;
Yano, H ;
Kumabe, T ;
Hayabuchi, N ;
Hisatomi, J ;
Sata, M ;
Kojiro, M .
JOURNAL OF HEPATOLOGY, 2004, 41 (06) :992-998