Disseminated fusarium infection after allogeneic hematopoietic stem cell transplantation after CART A case report

被引：4

作者：

Fei, Hairong ^{[1
]}

Liu, Xiaodan ^{[1
]}

Sun, Lingjie ^{[1
]}

Shi, Xue ^{[1
]}

Wang, Wei ^{[1
]}

Zhao, Hongguo ^{[1
]}

Zhao, Chunting ^{[1
]}

机构：

[1] Affiliated Hosp Qingdao Univ, Dept Hematol, Qingdao 266003, Shandong, Peoples R China

来源：

MEDICINE | 2022年 / 101卷 / 45期

关键词：

B-cell acute lymphoblastic leukemia; chimeric antigen receptor-modified T cells; Allogeneic hematopoietic stem cell transplantation; Immunosuppression; Fusarium infection; INVASIVE FUSARIOSIS;

D O I：

10.1097/MD.0000000000031594

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Fusarium is a conditional pathogen that can cause invasive infection in patients with hematological diseases under immune function. Methods: A case of recurrent and refractory Philadelphia chromosome-positive acute lymphoblastic leukemia was treated with allogeneic hematopoietic stem cell transplantation after chimeric antigen receptor-modified T cells treatment. Results: During transplantation, disseminated Fusarium infection occurred, involving the skin, liver, spleen and central nervous system, and the patient eventually died. Conclusions: Early identification of Fusarium infection based on the characteristic rash and timely antifungal treatment can improve the cure rate.

引用

页数：4

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