Effect of percutaneous ethanol injection in treatment of non-functioning benign solid thyroid nodules

被引:0
作者
Aliasgarzadeh, Akbar [2 ]
Javadrashid, Reza [1 ]
Ostadahmadli, Yashar
机构
[1] Tabriz Univ Med Sci, Fac Med, Tabriz, Iran
[2] Tabriz Univ Med Sci, Imam Reza Teaching Hosp, Endocrine Sect, Bone Res Ctr, Tabriz, Iran
关键词
Thyroid nodules; Management; Percutaneous Ethanol Injection; TERM-FOLLOW-UP; RADIOFREQUENCY ABLATION; EFFICACY; MANAGEMENT; THERAPY; SAFETY; CYSTS;
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective: Percutaneous Ethanol Injection (PEI) is a simple effective procedure especially in the treatment of autonomous and cystic thyroid nodules. In this study, we investigated the effect of PEI in volume reduction of nonfunctioning benign solid thyroid nodules. Methodology: In a prospective study, 62 euthyroid patients with benign thyroid nodules were selected consecutively by endocrinologist from those being visited at endocrinology clinics of Tabriz University of Medical Sciences, Iran during January 2007 to January 2008. The injection volume was set as two third of the nodule total size in cm(3) according to the ultrasonographic measurements with an upper limit volume of 10cc. The patients were followed up one week after injection for possible complications, and then 3 and 6 months later for evaluation of efficacy of intervention by ultrasound. Student t and Chi-square tests were used for statistical analysis and a P-value < 0.05 was considered as statistically significant Results: The data of 57 patients was used in the final analysis among which 5(8.8%) were male and 52(91.2%) were female. After six months of follow-up, the reduction in nodule size was < 30% in 15(26.3%) patients, between 31% and 50% in 14(24.6%) patients, and more than 50% in 28(49.1%) patients which was statistically significant (P = 0.001). Local pain in first week after injection was the main complication. Conclusion: Percutaneous Ethanol Injection (PEI) therapy can be a safe and effective method in the treatment of benign solid nonfunctioning thyroid nodules.
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页码:706 / 709
页数:4
相关论文
共 17 条
[1]   Treatment of recurrent thyroid cysts with ethanol:: A randomized double-blind controlled trial [J].
Bennedbæk, FN ;
Hegedüs, L .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2003, 88 (12) :5773-5777
[2]   Management of the nontoxic multinodular goiter:: A north American survey [J].
Bonnema, SJ ;
Bennedbæk, FN ;
Ladenson, PW ;
Hegedüs, L .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2002, 87 (01) :112-117
[3]   Percutaneous ethanol injection efficacy in the treatment of large symptomatic thyroid cystic nodules: Ten-year follow-up of a large series [J].
Del Prete, S ;
Caraglia, M ;
Russo, D ;
Vitale, G ;
Giuberti, G ;
Marra, M ;
D'Alessandro, AM ;
Lupoli, G ;
Addeo, R ;
Facchini, G ;
Rossiello, R ;
Abbruzzese, A ;
Capasso, E .
THYROID, 2002, 12 (09) :815-821
[4]   Nonsurgical approaches to the management of thyroid nodules [J].
Filetti, Sebastiano ;
Durante, Cosimo ;
Torlontano, Massimo .
NATURE CLINICAL PRACTICE ENDOCRINOLOGY & METABOLISM, 2006, 2 (07) :384-394
[5]   Percutaneous ethanol injection treatment in benign thyroid lesions: Role and efficacy [J].
Guglielmi, R ;
Pacella, CM ;
Bianchini, A ;
Bizzarri, G ;
Rinaldi, R ;
Graziano, FM ;
Petrucci, L ;
Toscano, V ;
Palma, E ;
Poggi, M ;
Papini, E .
THYROID, 2004, 14 (02) :125-131
[6]   Radiofrequency ablation of benign thyroid nodules: safety and imaging follow-up in 236 patients [J].
Jeong, Woo Kyoung ;
Baek, Jung Hwan ;
Rhim, Hyunchul ;
Kim, Yoon Suk ;
Kwak, Min Sook ;
Jeong, Hyun Jo ;
Lee, Ducky .
EUROPEAN RADIOLOGY, 2008, 18 (06) :1244-1250
[7]   Efficacy of sonographically guided percutaneous ethanol injection for treatment of thyroid cysts versus solid thyroid nodules [J].
Kim, JH ;
Lee, HK ;
Lee, JH ;
Ahn, IM ;
Choi, CG .
AMERICAN JOURNAL OF ROENTGENOLOGY, 2003, 180 (06) :1723-1726
[8]   Effectiveness of percutaneous ethanol injection therapy in benign nodular and cystic thyroid diseases: Long-term follow-up experience [J].
Lee, SJ ;
Ahn, IM .
ENDOCRINE JOURNAL, 2005, 52 (04) :455-462
[9]   Percutaneous ethanol injection therapy for locally recurrent papillary thyroid carcinoma [J].
Lim, Chi Young ;
Yun, Ji-Sup ;
Lee, Jandee ;
Nam, Kee-Hyun ;
Chung, Woong Youn ;
Park, Cheong Soo .
THYROID, 2007, 17 (04) :347-350
[10]  
MARTINO E, 1992, SURGERY, V112, P1161