Glutamine in the pathogenesis of acute hepatic encephalopathy
被引:28
作者:
Rao, Kakulavarapu V. Rama
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Univ Miami, Miller Sch Med, Dept Pathol, Miami, FL 33125 USAUniv Miami, Miller Sch Med, Dept Pathol, Miami, FL 33125 USA
Rao, Kakulavarapu V. Rama
[1
]
Jayakumar, Arumugam R.
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Univ Miami, Miller Sch Med, Dept Pathol, Miami, FL 33125 USA
Vet Affairs Med Ctr, Miami, FL 33125 USAUniv Miami, Miller Sch Med, Dept Pathol, Miami, FL 33125 USA
Jayakumar, Arumugam R.
[1
,2
]
Norenberg, Michael D.
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Univ Miami, Miller Sch Med, Dept Pathol, Miami, FL 33125 USA
Vet Affairs Med Ctr, Miami, FL 33125 USAUniv Miami, Miller Sch Med, Dept Pathol, Miami, FL 33125 USA
Norenberg, Michael D.
[1
,2
]
机构:
[1] Univ Miami, Miller Sch Med, Dept Pathol, Miami, FL 33125 USA
Hepatic encephalopathy (HE) is the major neurological disorder associated with liver disease. It presents in chronic and acute forms, and astrocytes are the major neural cells involved. While the principal etiological factor in the pathogenesis of HE is increased levels of blood and brain ammonia, glutamine, a byproduct of ammonia metabolism, has also been implicated in its pathogenesis. This article reviews the current status of glutamine in the pathogenesis of HE, particularly its involvement in some of the events triggered by ammonia, including mitochondrial dysfunction, generation of oxidative stress, and alterations in signaling mechanisms, including activation of mitogen-activated protein kinases (MAPKs) and nuclear factor-kappaB (NF-kappa B). Mechanisms by which glutamine contributes to astrocyte swelling/brain edema associated with acute liver failure (ALF) will also be described. Published by Elsevier Ltd.
机构:
Univ Montreal, CHUM, Neurosci Res Unit, Hop St Luc, Montreal, PQ H2X 3J4, CanadaUniv Montreal, CHUM, Neurosci Res Unit, Hop St Luc, Montreal, PQ H2X 3J4, Canada
Bemeur, Chantal
Qu, Hong
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Univ Montreal, CHUM, Neurosci Res Unit, Hop St Luc, Montreal, PQ H2X 3J4, CanadaUniv Montreal, CHUM, Neurosci Res Unit, Hop St Luc, Montreal, PQ H2X 3J4, Canada
Qu, Hong
Desjardins, Paul
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Univ Montreal, CHUM, Neurosci Res Unit, Hop St Luc, Montreal, PQ H2X 3J4, CanadaUniv Montreal, CHUM, Neurosci Res Unit, Hop St Luc, Montreal, PQ H2X 3J4, Canada
Desjardins, Paul
Butterworth, Roger F.
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Univ Montreal, CHUM, Neurosci Res Unit, Hop St Luc, Montreal, PQ H2X 3J4, CanadaUniv Montreal, CHUM, Neurosci Res Unit, Hop St Luc, Montreal, PQ H2X 3J4, Canada
机构:
Univ Montreal, CHUM, Neurosci Res Unit, Hop St Luc, Montreal, PQ H2X 3J4, CanadaUniv Montreal, CHUM, Neurosci Res Unit, Hop St Luc, Montreal, PQ H2X 3J4, Canada
Bemeur, Chantal
Qu, Hong
论文数: 0引用数: 0
h-index: 0
机构:
Univ Montreal, CHUM, Neurosci Res Unit, Hop St Luc, Montreal, PQ H2X 3J4, CanadaUniv Montreal, CHUM, Neurosci Res Unit, Hop St Luc, Montreal, PQ H2X 3J4, Canada
Qu, Hong
Desjardins, Paul
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h-index: 0
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Univ Montreal, CHUM, Neurosci Res Unit, Hop St Luc, Montreal, PQ H2X 3J4, CanadaUniv Montreal, CHUM, Neurosci Res Unit, Hop St Luc, Montreal, PQ H2X 3J4, Canada
Desjardins, Paul
Butterworth, Roger F.
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h-index: 0
机构:
Univ Montreal, CHUM, Neurosci Res Unit, Hop St Luc, Montreal, PQ H2X 3J4, CanadaUniv Montreal, CHUM, Neurosci Res Unit, Hop St Luc, Montreal, PQ H2X 3J4, Canada