[3] McGill Univ, Biomed Mass Spectrometry Unit, Montreal, PQ H3A 1A3, Canada
来源:
JOURNAL OF NATURAL PRODUCTS
|
1999年
/
62卷
/
09期
关键词:
D O I:
10.1021/np990160s
中图分类号:
Q94 [植物学];
学科分类号:
071001 ;
摘要:
Five novel taxanes (1-5) have been isolated from the needles of Taxus canadensis, and their structures were elucidated on the basis of spectroscopic data. Two of these taxanes have structural features seldom found in yews, with a C-12, C-13 double bond and a hydroxymethylene at C-4. In addition, the 2D structures generated by molecular modeling of taxanes 1 and 2, differing mostly in the location of the double bond in ring A, were compared. The different conformation of ring A derived from the C-12, C-13 double band is particularly interesting because it implies that if a Taxol (paclitaxel) side chain were attached to C-13 it would have a different orientation from that in paclitaxel.
机构:
Hebei Med Univ, Sch Pharmaceut Sci, Shijiazhuang 050017, Hebei, Peoples R China
Hebei Med Univ, Coll Basic Med Sci, Shijiazhuang 050017, Hebei, Peoples R ChinaHebei Med Univ, Sch Pharmaceut Sci, Shijiazhuang 050017, Hebei, Peoples R China
Zhang, Manli
Lu, Xinhua
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机构:
Hebei Med Univ, Sch Pharmaceut Sci, Shijiazhuang 050017, Hebei, Peoples R China
Hebei Med Univ, Coll Basic Med Sci, Shijiazhuang 050017, Hebei, Peoples R ChinaHebei Med Univ, Sch Pharmaceut Sci, Shijiazhuang 050017, Hebei, Peoples R China
Lu, Xinhua
Zhang, Jing
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机构:
Hebei Med Univ, Affiliated Hosp 3, Shijiazhuang 050000, Hebei, Peoples R ChinaHebei Med Univ, Sch Pharmaceut Sci, Shijiazhuang 050017, Hebei, Peoples R China
Zhang, Jing
Zhang, Shaoxia
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机构:
Yanshan Peoples Hosp, Yanshan 061300, Hebei, Peoples R ChinaHebei Med Univ, Sch Pharmaceut Sci, Shijiazhuang 050017, Hebei, Peoples R China
Zhang, Shaoxia
Dong, Mei
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h-index: 0
机构:
Hebei Med Univ, Dept Forens Med, Shijiazhuang 050017, Hebei, Peoples R ChinaHebei Med Univ, Sch Pharmaceut Sci, Shijiazhuang 050017, Hebei, Peoples R China
Dong, Mei
Huo, Changhong
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机构:
Hebei Med Univ, Sch Pharmaceut Sci, Shijiazhuang 050017, Hebei, Peoples R China
Hebei Med Univ, Coll Basic Med Sci, Shijiazhuang 050017, Hebei, Peoples R ChinaHebei Med Univ, Sch Pharmaceut Sci, Shijiazhuang 050017, Hebei, Peoples R China
Huo, Changhong
Shi, Qingwen
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h-index: 0
机构:
Hebei Med Univ, Sch Pharmaceut Sci, Shijiazhuang 050017, Hebei, Peoples R China
Hebei Med Univ, Coll Basic Med Sci, Shijiazhuang 050017, Hebei, Peoples R ChinaHebei Med Univ, Sch Pharmaceut Sci, Shijiazhuang 050017, Hebei, Peoples R China
Shi, Qingwen
Gu, Yucheng
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h-index: 0
机构:
Syngenta Jealotts Hill Int Res Ctr, Bracknell RG42 6EY, Berks, EnglandHebei Med Univ, Sch Pharmaceut Sci, Shijiazhuang 050017, Hebei, Peoples R China
Gu, Yucheng
Cong, Bin
论文数: 0引用数: 0
h-index: 0
机构:
Hebei Med Univ, Dept Forens Med, Shijiazhuang 050017, Hebei, Peoples R ChinaHebei Med Univ, Sch Pharmaceut Sci, Shijiazhuang 050017, Hebei, Peoples R China