LDL receptor-related proteins 5 and 6 in Wnt/β-catenin signaling:: Arrows point the way

被引：853

作者：

He, X ^{[1
]}

Semenov, M ^{[1
]}

Tamai, K ^{[1
]}

Zeng, X ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Childrens Hosp, Div Neurosci, Boston, MA 02115 USA

来源：

DEVELOPMENT | 2004年 / 131卷 / 08期

关键词：

D O I：

10.1242/dev.01117

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Wnt signaling through the canonical P-catenin pathway plays essential roles in development and disease. Low-density-lipoprotein receptor-related proteins 5 and 6 (Lrp5 and Lrp6) in vertebrates, and their Drosophila ortholog Arrow, are single-span transmembrane proteins that are indispensable for Wnt/beta-catenin signaling, and are likely to act as Wnt co-receptors. This review highlights recent progress and unresolved issues in understanding the function and regulation of Arrow/Lrp5/Lrp6 in Wnt signaling. We discuss Arrow/Lrp5/Lrp6 interactions with Wnt and the Frizzled family of Wnt receptors, and with the intracellular beta-catenin degradation apparatus. We also discuss the regulation of Lrp5/Lrp6 by other extracellular ligands, and LRP5 mutations associated with familial osteoporosis and other disorders.

引用

页码：1663 / 1677

页数：15

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