LDL receptor-related proteins 5 and 6 in Wnt/β-catenin signaling:: Arrows point the way

被引：853

作者：

He, X ^{[1
]}

Semenov, M ^{[1
]}

Tamai, K ^{[1
]}

Zeng, X ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Childrens Hosp, Div Neurosci, Boston, MA 02115 USA

来源：

DEVELOPMENT | 2004年 / 131卷 / 08期

关键词：

D O I：

10.1242/dev.01117

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Wnt signaling through the canonical P-catenin pathway plays essential roles in development and disease. Low-density-lipoprotein receptor-related proteins 5 and 6 (Lrp5 and Lrp6) in vertebrates, and their Drosophila ortholog Arrow, are single-span transmembrane proteins that are indispensable for Wnt/beta-catenin signaling, and are likely to act as Wnt co-receptors. This review highlights recent progress and unresolved issues in understanding the function and regulation of Arrow/Lrp5/Lrp6 in Wnt signaling. We discuss Arrow/Lrp5/Lrp6 interactions with Wnt and the Frizzled family of Wnt receptors, and with the intracellular beta-catenin degradation apparatus. We also discuss the regulation of Lrp5/Lrp6 by other extracellular ligands, and LRP5 mutations associated with familial osteoporosis and other disorders.

引用

页码：1663 / 1677

页数：15

共 141 条

[1] Planar signaling and morphogenesis in Drosophila [J].

Adler, PN .

DEVELOPMENTAL CELL, 2002, 2 (05) :525-535

[2]

Axelrod JD, 2001, GENE DEV, V15, P1182

[3] Differential recruitment of Dishevelled provides signaling specificity in the planar cell polarity and Wingless signaling pathways [J].

Axelrod, JD ;

Miller, JR ;

Shulman, JM ;

Moon, RT ;

Perrimon, N .

GENES & DEVELOPMENT, 1998, 12 (16) :2610-2622

[4] High bone mass in mice expressing a mutant LRP5 gene [J].

Babij, P ;

Zhao, WG ;

Small, C ;

Kharode, Y ;

Yaworsky, PJ ;

Bouxsein, ML ;

Reddy, PS ;

Bodine, PVN ;

Robinson, JA ;

Bhat, B ;

Marzolf, J ;

Moran, RA ;

Bex, F .

JOURNAL OF BONE AND MINERAL RESEARCH, 2003, 18 (06) :960-974

[5] Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow [J].

Bafico, A ;

Liu, GZ ;

Yaniv, A ;

Gazit, A ;

Aaronson, SA .

NATURE CELL BIOLOGY, 2001, 3 (07) :683-686

[6] Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST) [J].

Balemans, W ;

Ebeling, M ;

Patel, N ;

Van Hul, E ;

Olson, P ;

Dioszegi, M ;

Lacza, C ;

Wuyts, W ;

Van den Ende, J ;

Willems, P ;

Paes-Alves, AF ;

Hill, S ;

Bueno, M ;

Ramos, FJ ;

Tacconi, P ;

Dikkers, FG ;

Stratakis, C ;

Lindpaintner, K ;

Vickery, B ;

Foernzler, D ;

Van Hul, W .

HUMAN MOLECULAR GENETICS, 2001, 10 (05) :537-543

[7] Functional interaction of an axin homolog, conductin, with β-catenin, APC, and GSK3β [J].

Behrens, J ;

Jerchow, BA ;

Würtele, M ;

Grimm, J ;

Asbrand, C ;

Wirtz, R ;

Kühl, M ;

Wedlich, D ;

Birchmeier, W .

SCIENCE, 1998, 280 (5363) :596-599

[8]

Belenkaya TY, 2002, DEVELOPMENT, V129, P4089

[9] A new member of the frizzled family from Drosophila functions as a Wingless receptor [J].

Bhanot, P ;

Brink, M ;

Samos, CH ;

Hsieh, JC ;

Wang, YS ;

Macke, JP ;

Andrew, D ;

Nathans, J ;

Nusse, R .

NATURE, 1996, 382 (6588) :225-230

[10]

Bhanot P, 1999, DEVELOPMENT, V126, P4175

← 1 2 3 4 5 6 7 8 9 10 →