LDL receptor-related proteins 5 and 6 in Wnt/β-catenin signaling:: Arrows point the way

被引：844
作者：
He, X [1 ]
Semenov, M [1 ]
Tamai, K [1 ]
Zeng, X [1 ]
机构：
[1] Harvard Univ, Sch Med, Childrens Hosp, Div Neurosci, Boston, MA 02115 USA
来源：
DEVELOPMENT | 2004年 / 131卷 / 08期
关键词：
D O I：
10.1242/dev.01117
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Wnt signaling through the canonical P-catenin pathway plays essential roles in development and disease. Low-density-lipoprotein receptor-related proteins 5 and 6 (Lrp5 and Lrp6) in vertebrates, and their Drosophila ortholog Arrow, are single-span transmembrane proteins that are indispensable for Wnt/beta-catenin signaling, and are likely to act as Wnt co-receptors. This review highlights recent progress and unresolved issues in understanding the function and regulation of Arrow/Lrp5/Lrp6 in Wnt signaling. We discuss Arrow/Lrp5/Lrp6 interactions with Wnt and the Frizzled family of Wnt receptors, and with the intracellular beta-catenin degradation apparatus. We also discuss the regulation of Lrp5/Lrp6 by other extracellular ligands, and LRP5 mutations associated with familial osteoporosis and other disorders.
引用
收藏
页码：1663 / 1677
页数：15
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