Staphylococci: colonizers and pathogens of human skin

被引：111

作者：

Coates, Rosanna ^{[1
]}

Moran, Josephine ^{[1
]}

Horsburgh, Malcolm J. ^{[1
]}

机构：

[1] Univ Liverpool, Inst Integrat Biol, Microbiol Res Grp, Liverpool L69 7ZB, Merseyside, England

来源：

FUTURE MICROBIOLOGY | 2014年 / 9卷 / 01期

基金：

英国生物技术与生命科学研究理事会;

关键词：

adhesin; antimicrobial peptide; commensal; desiccation; fatty acid; pathogen; skin colonization; sphingosine; Staphylococcus; AUREUS NASAL COLONIZATION; FIBRONECTIN-BINDING PROTEIN; WALL TEICHOIC-ACID; PERMEABILITY BARRIER HOMEOSTASIS; ANTIMICROBIAL FATTY-ACIDS; CATABOLIC MOBILE ELEMENT; PHENOL-SOLUBLE MODULINS; PEPTIDE-SENSING SYSTEM; VRAFG ABC TRANSPORTER; MODIFYING ENZYME FAME;

D O I：

10.2217/fmb.13.145

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Staphylococci are abundant bacteria of the human skin microbiome. Several species, particularly Staphylococcus aureus and Staphylococcus epidermidis, are opportunistic pathogens and cause significant disease. The human skin serves many functions and here we review its role as an antimicrobial barrier and the staphylococcal mechanisms to colonize and counteract the various stresses present in this niche. Successful colonization is achieved using a diversity of adhesins, surface proteins and secreted enzymes to counteract the antimicrobial peptides, enzymes and lipid matrix components present in the acid mantle. Further mechanisms enable these bacteria to overcome osmotic and acid stresses and desiccation in order to survive the exacting demands of an ever-changing landscape.

引用

页码：75 / 91

页数：17

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