Neonatal CSF oxytocin levels are associated with parent report of infant soothability and sociability

被引：45

作者：

Clark, Catherine L. ^{[1
]}

St John, Nicholas ^{[2
]}

Pasca, Anca M. ^{[1
]}

Hyde, Shellie A. ^{[3
]}

Hornbeak, Kirsten ^{[3
]}

Abramova, Marina ^{[1
]}

Feldman, Heidi ^{[1
]}

Parker, Karen J. ^{[3
]}

Penn, Anna A. ^{[1
]}

机构：

[1] Stanford Univ, Sch Med, Dept Pediat, Div Neonatal & Dev Med, Stanford, CA 94305 USA

[2] Lucile Packard Childrens Hosp Stanford, Palo Alto, CA 94304 USA

[3] Stanford Univ, Sch Med, Dept Psychiat, Stanford, CA 94305 USA

来源：

PSYCHONEUROENDOCRINOLOGY | 2013年 / 38卷 / 07期

关键词：

Oxytocin; CSF; Newborn; Social behavior; Soothability; Social engagement; CEREBROSPINAL-FLUID; RHESUS-MONKEYS; VASOPRESSIN; PLASMA; MACAQUES; BEHAVIOR;

D O I：

10.1016/j.psyneuen.2012.10.017

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Oxytocin (OT) has been linked to social behavior in rodents, non-human primates, and adult humans, but almost nothing is known about brain OT activity in human newborns or its impact on social development. To better understand the role of OT biology in human social functioning, a multi-disciplinary, longitudinal study was conducted. Cerebral spinal fluid (CSF) OT levels from 18 human neonates were evaluated and examined in relationship to social-seeking behavior at term, at 3 months, and at 6 months of age. Higher neonatal CSF OT levels were consistently associated with solicitation of parental soothing and interest in social engagement with others. This is the first study to link CSF OT levels to normative human social functioning. Research is now required to test whether early OT levels serve as a biomarker for subsequent social abnormalities. (c) 2012 Elsevier Ltd. All rights reserved.

引用

页码：1208 / 1212

页数：5

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