A phase 2 study of ONC201 in recurrent/refractory metastatic breast cancer and advanced endometrial carcinoma

被引:0
|
作者
Gatti-Mays, Margaret E.
Greer, Yoshimi
Steinberg, Seth
Soltani, Sanaz
Collins, Julie
Olson, Michelle
Ojemuyiwa, Michelle
Annunziata, Christina
Lee, Jung-Min
Nunes, Ana
Lipkowitz, Stan
Zimmer, Alexandra
机构
[1] NCI, Womens Malignancies Branch, NIH, Bethesda, MD 20892 USA
[2] NCI, NIH, Bethesda, MD 20892 USA
[3] Walter Reed Natl Mil Med Ctr, Murtha Canc Ctr, Bethesda, MD USA
关键词
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
OT2-07-04
引用
收藏
页数:1
相关论文
共 50 条
  • [1] A Single-Arm, Open-Label Phase II Study of ONC201 in Recurrent/Refractory Metastatic Breast Cancer and Advanced Endometrial Carcinoma
    Atkins, Sarah L. P.
    Greer, Yoshimi Endo
    Jenkins, Sarah
    Gatti-Mays, Margaret E.
    Houston, Nicole
    Lee, Sunmin
    Lee, Min-Jung
    Rastogi, Shraddha
    Sato, Nahoko
    Burks, Christina
    Annunziata, Christina M.
    Lee, Jung-Min
    Nagashima, Kunio
    Trepel, Jane B.
    Lipkowitz, Stanley
    Zimmer, Alexandra S.
    ONCOLOGIST, 2023, 28 (10): : E919 - E972
  • [2] Clinical activity of the selective DRD2 antagonist ONC201, an imipridone, in metastatic endometrial cancer (mEC).
    Rodriguez-Rodriguez, Lorna
    Mehnert, Janice M.
    Silk, Ann W.
    Chan, Nancy
    Malhotra, Jyoti
    Aisner, Joseph
    Saunders, Tracie
    Yu, Bangning
    Dickerson, Siobhan
    Tarapore, Rohinton
    Allen, Joshua E.
    Stogniew, Martin
    Oster, Wolfgang
    Kaufman, Howard
    Haffty, Bruce George
    Bertino, Joseph R.
    Stein, Mark N.
    JOURNAL OF CLINICAL ONCOLOGY, 2017, 35
  • [3] Immunomodulatory activity of selective DRD2 antagonist ONC201, an imipridone, in metastatic endometrial cancer (mEC)
    Tarapore, Rohinton S.
    Prabhu, Varun V.
    Mok, Samuel C.
    Yeung, Chilam Au
    Rodriguez, Lorna
    Girda, Eugenia
    Mantia-Smaldone, Gina
    Bae-Jump, Victoria
    Lu, Guangrong
    Oster, Wolfgang
    Allen, Joshua E.
    CANCER RESEARCH, 2020, 80 (16)
  • [4] ONC201 kills breast cancer cells by targeting mitochondria
    Greer, Yoshimi Endo
    Gilbert, Samuel
    Islam, Celia
    Ubaldini, Ashley
    Stuelten, Christina
    Porat-Shliom, Natalie
    Weigert, Roberto
    Ji, Yun
    Gattinoni, Luca
    Soheilian, Ferri
    Nagashima, Kunio
    Wang, Xiantao
    Hafner, Markus
    Shetty, Jyoti
    Tran, Bao
    Koparde, Vishal
    Jailwala, Parthav
    Cam, Maggie
    Crooks, Dan
    Linehan, W. Marston
    Voeller, Donna
    Reinhold, William
    Rajapakse, Vinodh
    Pommier, Yves
    Lipkowitz, Stanley
    MOLECULAR CANCER THERAPEUTICS, 2018, 17 (01)
  • [5] ONC201 Depletes Cancer Stem Cells in Refractory Cancer Patient Samples
    Prabhu, Varun Vijay
    Ishizawa, Jo
    Zhao, Dan
    Allen, Joshua E.
    Batchelor, Tracy T.
    Chi, Andrew S.
    Andreeff, Michael
    El-Deiry, Wafik S.
    BLOOD, 2014, 124 (21)
  • [6] Combination ONC201 and radiation therapy in the treatment of breast cancer
    Jhawar, Sachin R.
    Schiff, Devora
    Wu, Hao
    Thandoni, Aditya
    Hassan, Suemair
    Allen, Joshua
    Stogniew, Martin
    Tarapore, Rohinton
    Oster, Wolfgang
    Stein, Mark
    Silk, Ann W.
    Goyal, Sharad
    Haffty, Bruce G.
    Zloza, Andrew
    CANCER RESEARCH, 2018, 78 (13)
  • [7] ONC201 kills breast cancer cells by inhibiting mitochondrial respiration
    Greer, Y. E.
    Gilbert, S. F.
    Islam, C.
    Ji, Y.
    Gattinoni, L.
    Stuelten, C.
    Voeller, D.
    Lipkowitz, S.
    CANCER RESEARCH, 2017, 77
  • [8] ONC201 kills breast cancer cells by inhibiting mitochondrial respiration
    Greer, Yoshimi
    Gilbert, Samuel
    Islam, Celia
    Ji, Yun
    Gattinoni, Luca
    Stuelten, Christina
    Porat-Shliom, Natalie
    Weigert, Roberto
    Wang, Xiantao
    Hafner, Markus
    Nagashima, Kunio
    Voeller, Donna
    Lipkowitz, Stanley
    CANCER RESEARCH, 2017, 77
  • [9] Antitumorigenic effect of combination treatment with ONC201 and TRAIL in endometrial cancer in vitro and in vivo
    Ray, Jocelyn E.
    Ralff, Marie D.
    Jhaveri, Aakash
    Zhou, Lanlan
    Dicker, David T.
    Ross, Eric A.
    El-Deiry, Wafik S.
    CANCER BIOLOGY & THERAPY, 2021, 22 (10-12) : 554 - 563
  • [10] Clinical activity of ONC201 in metastatic castrate resistant prostate cancer (mCRPC).
    Stein, Mark N.
    Kaufman, Howard
    Benes, Cyril
    Stogniew, Martin
    Oster, Wolfgang
    Allen, Joshua E.
    Haffty, Bruce George
    Bertino, Joseph R.
    JOURNAL OF CLINICAL ONCOLOGY, 2016, 34 (15)