Photodynamic Therapy Leads to Complete Remission of Tongue Tumors and Inhibits Metastases to Regional Lymph Nodes

被引：28
作者：
Bicalho, Leandro Santos [1 ]
Figueiro Longo, Joao Paulo [1 ]
Oliveira Cavalcanti, Claudio Eduardo [1 ]
Simioni, Andreza Ribeiro [2 ]
Bocca, Anamelia Lorenzetti [3 ]
Menezes de Almeida Santos, Maria de Fatima [1 ]
Tedesco, Antonio Claudio [4 ]
Azevedo, Ricardo Bentes [1 ]
机构：
[1] Univ Brasilia, Inst Ciencias Biol, Dept Genet & Morfol, Lab Nanobiotecnol, BR-70910970 Brasilia, DF, Brazil
[2] Univ Vale do Paraiba, Inst Pesquisa & Dev, BR-12244000 Sao Jose Dos Campos, Brazil
[3] Univ Brasilia, Inst Ciencias Biol, Dept Biol Celular, Lab Imunol Aplicada, BR-70910900 Brasilia, DF, Brazil
[4] Univ Sao Paulo, Fac Filosofia Ciencias & Letras Ribeirao Preto, Grp Fotobiol & Fotomed, Dept Quim, BR-14040901 Ribeirao Preto, SP, Brazil
来源：
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY | 2013年 / 9卷 / 05期
基金：
巴西圣保罗研究基金会;
关键词：
Photodynamic Therapy; Oral Cancer; Metastasis; Liposome; Lymph Node; LIPOSOMES; PHTHALOCYANINE; CANCER;
D O I：
10.1166/jbn.2013.1589
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
In patients diagnosed with oral cancer, the most important prognostic indicator for patient survival after primary treatment is metastasis to the cervical lymph nodes or distal sites. Therefore, we evaluated the utility of photodynamic therapy (PDT) mediated by aluminum-chloride-phthalocyanine entrapped in liposomes for the prevention of metastasis to regional cervical lymph nodes in the Erhlich tongue cancer model. The PDT protocol led to complete remission of tongue tumours and prevented the occurrence of regional metastasis. The prevention of regional metastasis was confirmed by histopathological and immunohistochemical analyses. In addition, PDT treatment increased the overall survival and reduced weight loss relative to control tumour-bearing mice. Thus, PDT should be clinically evaluated for use in the prevention of cervical lymph node metastasis in patients with oral cancer.
引用
收藏
页码：811 / 818
页数：8
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